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| Verfasst von: | Kobbe, Guido [VerfasserIn]  |
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| | Brüggemann, Monika [VerfasserIn] |
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| | Baermann, Ben-Niklas [VerfasserIn] |
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| | Wiegand, Laura [VerfasserIn] |
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| | Trautmann, Heiko [VerfasserIn] |
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| | Yousefian, Schayan [VerfasserIn] |
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| | Libertini, Silvana [VerfasserIn] |
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| | Menssen, Hans D. [VerfasserIn] |
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| | Maier, Harald J. [VerfasserIn] |
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| | Ulrich, Peter [VerfasserIn] |
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| | Gao, Jingbo [VerfasserIn] |
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| | Bruch, Peter-Martin [VerfasserIn] |
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| | Liebers, Nora [VerfasserIn] |
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| | Radujković, Aleksandar [VerfasserIn] |
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| | Seifert, Marc [VerfasserIn] |
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| | Schniederjohann, Christina [VerfasserIn] |
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| | Paramasivam, Nagarajan [VerfasserIn] |
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| | Fitzgerald, Donnacha [VerfasserIn] |
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| | Seidel, Maximilian [VerfasserIn] |
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| | Esposito, Irene [VerfasserIn] |
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| | Germing, Ulrich [VerfasserIn] |
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| | Cadeddu, Ron-Patrick [VerfasserIn] |
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| | Nachtkamp, Kathrin [VerfasserIn] |
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| | Jäger, Paul [VerfasserIn] |
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| | Ulrych, Thomas [VerfasserIn] |
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| | Fischer, Johannes C. [VerfasserIn] |
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| | Rox, Jutta M. [VerfasserIn] |
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| | Giesel, Frederik L. [VerfasserIn] |
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| | Koch, Raphael [VerfasserIn] |
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| | Antoch, Gerald [VerfasserIn] |
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| | Distler, Jörg H. W. [VerfasserIn] |
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| | Meuth, Sven G. [VerfasserIn] |
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| | Jacobsen, Malte [VerfasserIn] |
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| | Hübschmann, Daniel [VerfasserIn] |
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| | Lu, Junyan [VerfasserIn] |
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| | Iaccarino, Ingram [VerfasserIn] |
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| | Haas, Simon [VerfasserIn] |
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| | Damm, Frederik [VerfasserIn] |
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| | Dietrich, Sascha [VerfasserIn] |
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| Titel: | Aggressive lymphoma after CD19 CAR T-cell therapy |
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| Titelzusatz: | brief report |
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| Verf.angabe: | G. Kobbe, M. Brüggemann, B.-N. Baermann, L. Wiegand, H. Trautmann, S. Yousefian, S. Libertini, H.D. Menssen, H.J. Maier, P. Ulrich, J. Gao, P.-M. Bruch, N. Liebers, A. Radujkovic, M. Seifert, C. Schniederjohann, N. Paramasivam, D. Fitzgerald, M. Seidel, I. Esposito, U. Germing, R.-P. Cadeddu, K. Nachtkamp, P. Jäger, T. Ulrych, J.C. Fischer, J.M. Rox, F. Giesel, R. Koch, G. Antoch, J.H.W. Distler, S.G. Meuth, M. Jacobsen, D. Hübschmann, J. Lu, I. Iaccarino, S. Haas, F. Damm, and S. Dietrich |
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| E-Jahr: | 2024 |
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| Jahr: | October 2, 2024 |
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| Umfang: | 10 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 03.06.2025 |
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| Titel Quelle: | Enthalten in: The New England journal of medicine |
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| Ort Quelle: | Waltham, Mass. : MMS, 1928 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 391(2024), 13, Seite 1217-1226 |
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| ISSN Quelle: | 1533-4406 |
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| Abstract: | The development of a fatal, clonal, autonomously proliferating CD4−CD8− chimeric antigen receptor (CAR)+ peripheral T-cell lymphoma (PTCL) occurred 1 month after a patient received treatment with tisagenlecleucel for relapsed primary central nervous system lymphoma. The PTCL had a clonal T-cell receptor rearrangement, which was already detectable in the apheresis product for CAR T-cell manufacturing and 7 months earlier for autologous transplantation. Somatic DNMT3A and TET2 mutations in CD34+ stem cells and their progeny were detected in the PTCL, in the apheresis specimen that was obtained for CAR T-cell production, and in the autotransplant. The PTCL harbored an additional somatic TET2 mutation, which was already detectable in the CAR T-cell apheresis product and the final CAR T-cell product at very low frequencies, providing evidence that clonal hematopoiesis had contributed to lymphomagenesis. Shortly after a patient received CAR T-cell therapy for relapsed CNS lymphoma, an aggressive CAR+ T-cell lymphoma was diagnosed. Subsequent analysis revealed the presence of an abnormal clone in an early apheresis specimen. |
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| DOI: | doi:10.1056/NEJMoa2402730 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1056/NEJMoa2402730 |
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| | Volltext: https://www.nejm.org/doi/full/10.1056/NEJMoa2402730 |
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| | DOI: https://doi.org/10.1056/NEJMoa2402730 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1927318068 |
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| Verknüpfungen: | → Zeitschrift |
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Aggressive lymphoma after CD19 CAR T-cell therapy / Kobbe, Guido [VerfasserIn]; October 2, 2024 (Online-Ressource)
