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| Verfasst von: | Ortí, Guillermo [VerfasserIn]  |
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| | Peczynski, Christophe [VerfasserIn] |
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| | Boreland, William [VerfasserIn] |
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| | O’Reilly, Maeve [VerfasserIn] |
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| | von Bonin, Malte [VerfasserIn] |
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| | Balduzzi, Adriana [VerfasserIn] |
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| | Besley, Caroline [VerfasserIn] |
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| | Kalwak, Krzysztof [VerfasserIn] |
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| | Ryhänen, Samppa [VerfasserIn] |
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| | Güngör, Tayfun [VerfasserIn] |
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| | Wynn, Robert F. [VerfasserIn] |
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| | Bader, Peter [VerfasserIn] |
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| | Mielke, Stephan [VerfasserIn] |
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| | Blaise, Didier [VerfasserIn] |
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| | Amrolia, Persis [VerfasserIn] |
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| | Yakoub-Agha, Ibrahim [VerfasserIn] |
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| | Calkoen, Friso [VerfasserIn] |
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| | Schubert, Maria-Luisa [VerfasserIn] |
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| | Potter, Victoria [VerfasserIn] |
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| | Pichler, Herbert [VerfasserIn] |
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| | Kröger, Nicolaus [VerfasserIn] |
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| | Kwon, Mi [VerfasserIn] |
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| | Sengeloev, Henrik [VerfasserIn] |
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| | Torrent, Anna [VerfasserIn] |
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| | Chalandon, Yves [VerfasserIn] |
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| | van Gorkom, Gwendolyn [VerfasserIn] |
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| | Könecke, Christian [VerfasserIn] |
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| | Graham, Charlotte [VerfasserIn] |
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| | Schoemans, Helene [VerfasserIn] |
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| | Moiseev, Ivan [VerfasserIn] |
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| | Penack, Olaf [VerfasserIn] |
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| | Peric, Zinaida [VerfasserIn] |
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| Titel: | Graft-versus-host disease after anti-CD19 chimeric antigen receptor T-cell therapy following allogeneic hematopoietic cell transplantation |
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| Titelzusatz: | a transplant complications and paediatric diseases working parties joint EBMT study |
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| Verf.angabe: | Guillermo Ortí, Christophe Peczynski, William Boreland, Maeve O’Reilly, Malte von Bonin, Adriana Balduzzi, Caroline Besley, Krzysztof Kalwak, Samppa Ryhänen, Tayfun Güngör, Robert F. Wynn, Peter Bader, Stephan Mielke, Didier Blaise, Persis Amrolia, Ibrahim Yakoub-Agha, Friso Calkoen, Maria-Luisa Schubert, Victoria Potter, Herbert Pichler, Nicolaus Kröger, Mi Kwon, Henrik Sengeloev, Anna Torrent, Yves Chalandon, Gwendolyn van Gorkom, Christian Koenecke, Charlotte Graham, Helene Schoemans, Ivan Moiseev and Olaf Penack, Zinaida Peric |
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| E-Jahr: | 2025 |
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| Jahr: | February 2025 |
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| Umfang: | 7 S. |
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| Illustrationen: | Diagramme |
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| Fussnoten: | Online verfügbar: 19. November 2024 ; Gesehen am 04.06.2025 |
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| Titel Quelle: | Enthalten in: Leukemia |
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| Ort Quelle: | London : Springer Nature, 1997 |
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| Jahr Quelle: | 2025 |
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| Band/Heft Quelle: | 39(2025), 2 vom: Feb., Seite 431-437 |
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| ISSN Quelle: | 1476-5551 |
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| Abstract: | In patients diagnosed with B-acute lymphoblastic leukemia (B-ALL) or B-non-Hodgkin’s lymphoma (B-NHL) relapsing after allogeneic stem cell transplantation (allo-HCT), it is a standard practice to perform anti-CD19 chimeric antigen receptor (CAR) T-cell therapy. When collected from the patient after allo-HCT, the produced CAR-T cells are likely to be donor T-cell-derived, creating unknown safety risks due to their potential allo-reactivity. We therefore performed an EBMT registry-based study on the incidence of graft-versus-host disease (GvHD) in this setting. We included 257 allo-HCT patients (n = 172 ≥ 18 years) with B-ALL or B-NHL, treated with anti-CD19 CAR T-cells (tisagenlecleucel n = 184, brexucabtagene autoleucel n = 43 and axicabtagene ciloleucel n = 30), between 2018 and 2022. Three patients developed aGvHD, whereas 6 patients developed cGvHD after CAR T-cell. The 100-day cumulative incidence (CI) of new aGvHD was 1.6% and the 12-month CI of new cGvHD was 2.8%. The 1-year GvHD relapse-free survival and non-relapse mortality were 52.1% and 4.7%, respectively. Last, with a median follow up of 18.8 months, the 1-year overall survival was 76.8%. In summary, the GvHD rate in allo-HCT patients treated with CAR T-cell therapy is relatively low. Our data support the view that GvHD is not a major safety issue in this setting. |
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| DOI: | doi:10.1038/s41375-024-02467-5 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41375-024-02467-5 |
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| | Volltext: https://www.nature.com/articles/s41375-024-02467-5 |
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| | DOI: https://doi.org/10.1038/s41375-024-02467-5 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Graft-versus-host disease |
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| | Immunotherapy |
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| K10plus-PPN: | 1927449936 |
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| Verknüpfungen: | → Zeitschrift |
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Graft-versus-host disease after anti-CD19 chimeric antigen receptor T-cell therapy following allogeneic hematopoietic cell transplantation / Ortí, Guillermo [VerfasserIn]; February 2025 (Online-Ressource)
