| |  Online-Ressource |
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| Verfasst von: | Yi, Buqing [VerfasserIn]  |
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| | Patrasová, Eva [VerfasserIn] |
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| | Šimůnková, Lenka [VerfasserIn] |
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| | Rost, Fabian [VerfasserIn] |
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| | Winkler, Sylke [VerfasserIn] |
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| | Laubner, Alexa [VerfasserIn] |
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| | Reinhardt, Susanne [VerfasserIn] |
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| | Dahl, Andreas [VerfasserIn] |
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| | Dalpke, Alexander [VerfasserIn] |
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| Titel: | Investigating the cause of a 2021 winter wave of COVID-19 in a border region in eastern Germany |
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| Titelzusatz: | a mixed-methods study, August to November 2021 |
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| Verf.angabe: | Buqing Yi, Eva Patrasová, Lenka Šimůnková, Fabian Rost, Sylke Winkler, Alexa Laubner, Susanne Reinhardt, Andreas Dahl and Alexander H. Dalpke |
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| E-Jahr: | 2024 |
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| Jahr: | 16 May 2024 |
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| Umfang: | 11 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 04.06.2025 |
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| Titel Quelle: | Enthalten in: Epidemiology and infection |
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| Ort Quelle: | Cambridge [u.a.] : Cambridge Univ. Press, 1987 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 152(2024), Artikel-ID e87, Seite 1-11 |
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| ISSN Quelle: | 1469-4409 |
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| Abstract: | It is so far unclear how the COVID-19 winter waves started and what should be done to prevent possible future waves. In this study, we deciphered the dynamic course of a winter wave in 2021 in Saxony, a state in Eastern Germany neighbouring the Czech Republic and Poland. The study was carried out through the integration of multiple virus genomic epidemiology approaches to track transmission chains, identify emerging variants and investigate dynamic changes in transmission clusters. For identified local variants of interest, functional evaluations were performed. Multiple long-lasting community transmission clusters have been identified acting as driving force for the winter wave 2021. Analysis of the dynamic courses of two representative clusters indicated a similar transmission pattern. However, the transmission cluster caused by a locally occurring new Delta variant AY.36.1 showed a distinct transmission pattern, and functional analyses revealed a replication advantage of it. This study indicated that long-lasting community transmission clusters starting since early autumn caused by imported or locally occurring variants all contributed to the development of the 2021 winter wave. The information we achieved might help future pandemic prevention. |
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| DOI: | doi:10.1017/S0950268824000761 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1017/S0950268824000761 |
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| | DOI: https://doi.org/10.1017/S0950268824000761 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | community transmission |
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| | COVID-19 |
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| | genomic epidemiology |
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| | genomic surveillance |
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| | Germany |
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| | Humans |
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| | pathogens |
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| | SARS-CoV-2 |
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| | Seasons |
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| | viral infection |
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| K10plus-PPN: | 1927469783 |
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| Verknüpfungen: | → Zeitschrift |
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Investigating the cause of a 2021 winter wave of COVID-19 in a border region in eastern Germany / Yi, Buqing [VerfasserIn]; 16 May 2024 (Online-Ressource)
