| |  Online-Ressource |
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| Verfasst von: | Spotorno, Viviana G. [VerfasserIn]  |
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| | Roxo, Mariana [VerfasserIn] |
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| | Wetterauer, Bernhard [VerfasserIn] |
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| | Zabal, Osvaldo A. [VerfasserIn] |
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| | Wink, Michael [VerfasserIn] |
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| Titel: | Effects on neuroprotection and α-synuclein expression of a <i>Canna coccinea</i> rhizome extract |
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| Verf.angabe: | Viviana G. Spotorno, Mariana Roxo, Bernhard Wetterauer, Osvaldo A. Zabal, Michael Wink |
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| E-Jahr: | 2025 |
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| Jahr: | 05 January 2025 |
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| Umfang: | 7 S. |
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| Illustrationen: | Diagramme |
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| Fussnoten: | Online verfügbar: 05. Januar 2025 ; Gesehen am 06.06.2025 |
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| Titel Quelle: | Enthalten in: Fitoterapia |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1999 |
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| Jahr Quelle: | 2025 |
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| Band/Heft Quelle: | 181(2025), Artikel-ID 106380, Seite 1-7 |
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| ISSN Quelle: | 1873-6971 |
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| Abstract: | Parkinson's disease (PD) is the second most common neurodegenerative disorder in the elderly, currently with no cure. Its mechanisms are not well understood, however α-synuclein protein aggregation plays a central role in the pathogenesis of PD, leading to neurodegeneration. We demonstrated that in a PD model dietary in Caenorhabditis elegans treatment with an extract from the rhizome of Canna coccinea decreased the accumulation of α-synuclein. The extract showed low toxicity to neuro 2a cells and protected them from oxidative damage with H2O2 as a model for neurodegeneration. We studied the chemical profile of the extract using liquid chromatography couple to Mass Spectrometry. In order to characterize the herbal extract, we quantified rosmarinic acid as a marker compound and measured its antioxidant activity in vitro. Altogether, apart from its potential as a functional food, Canna coccinea may be an interesting source of secondary metabolites in the development of potential novel anti-neurodegenerative drugs. |
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| DOI: | doi:10.1016/j.fitote.2025.106380 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.fitote.2025.106380 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0367326X2500005X |
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| | DOI: https://doi.org/10.1016/j.fitote.2025.106380 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Neuro 2 a |
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| | Neuroprotection |
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| | Parkinson's disease |
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| | α-Synuclein |
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| K10plus-PPN: | 1927683610 |
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| Verknüpfungen: | → Zeitschrift |
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Effects on neuroprotection and α-synuclein expression of a <i>Canna coccinea</i> rhizome extract / Spotorno, Viviana G. [VerfasserIn]; 05 January 2025 (Online-Ressource)
