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| Verfasst von: | Park, Yae Won [VerfasserIn]  |
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| | Choi, Kyu Sung [VerfasserIn] |
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| | Foltyn-Dumitru, Martha [VerfasserIn] |
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| | Brugnara, Gianluca [VerfasserIn] |
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| | Banan, Rouzbeh [VerfasserIn] |
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| | Kim, Sooyon [VerfasserIn] |
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| | Han, Kyunghwa [VerfasserIn] |
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| | Park, Ji Eun [VerfasserIn] |
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| | Keßler, Tobias [VerfasserIn] |
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| | Bendszus, Martin [VerfasserIn] |
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| | Krieg, Sandro [VerfasserIn] |
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| | Wick, Wolfgang [VerfasserIn] |
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| | Sahm, Felix [VerfasserIn] |
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| | Choi, Seung Hong [VerfasserIn] |
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| | Kim, Ho Sung [VerfasserIn] |
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| | Chang, Jong Hee [VerfasserIn] |
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| | Kim, Se Hoon [VerfasserIn] |
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| | Wongsawaeng, Doonyaporn [VerfasserIn] |
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| | Pollock, Jeffrey Michael [VerfasserIn] |
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| | Lee, Seung-Koo [VerfasserIn] |
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| | Barajas, Ramon Francisco, Jr [VerfasserIn] |
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| | Vollmuth, Philipp [VerfasserIn] |
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| | Ahn, Sung Soo [VerfasserIn] |
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| Titel: | Incorporating supramaximal resection into survival stratification of IDH-wildtype glioblastoma |
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| Titelzusatz: | a refined multi-institutional recursive partitioning analysis |
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| Verf.angabe: | Yae Won Park, Kyu Sung Choi, Martha Foltyn-Dumitru, Gianluca Brugnara, Rouzbeh Banan, Sooyon Kim, Kyunghwa Han, Ji Eun Park, Tobias Kessler, Martin Bendszus, Sandro Krieg, Wolfgang Wick, Felix Sahm, Seung Hong Choi, Ho Sung Kim, Jong Hee Chang, Se Hoon Kim, Doonyaporn Wongsawaeng, Jeffrey Michael Pollock, Seung-Koo Lee, Ramon Francisco, Jr Barajas, Philipp Vollmuth, and Sung Soo Ahn |
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| E-Jahr: | 2024 |
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| Jahr: | 1 November 2024 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 10.06.2025 |
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| Titel Quelle: | Enthalten in: Clinical cancer research |
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| Ort Quelle: | Philadelphia, Pa. [u.a.] : AACR, 1995 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 30(2024), 21 vom: Nov., Seite 4866-4875 |
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| ISSN Quelle: | 1557-3265 |
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| Abstract: | To propose a novel recursive partitioning analysis (RPA) classification model in patients with IDH-wildtype glioblastomas that incorporates the recently expanded conception of the extent of resection (EOR) in terms of both supramaximal and total resections.This multicenter cohort study included a developmental cohort of 622 patients with IDH-wildtype glioblastomas from a single institution (Severance Hospital) and validation cohorts of 536 patients from three institutions (Seoul National University Hospital, Asan Medical Center, and Heidelberg University Hospital). All patients completed standard treatment including concurrent chemoradiotherapy and underwent testing to determine their IDH mutation and MGMTp methylation status. EORs were categorized into either supramaximal, total, or non-total resections. A novel RPA model was then developed and compared with a previous Radiation Therapy Oncology Group (RTOG) RPA model.In the developmental cohort, the RPA model included age, MGMTp methylation status, Karnofsky performance status, and EOR. Younger patients with MGMTp methylation and supramaximal resections showed a more favorable prognosis [class I: median overall survival (OS) 57.3 months], whereas low-performing patients with non-total resections and without MGMTp methylation showed the worst prognosis (class IV: median OS 14.3 months). The prognostic significance of the RPA was subsequently confirmed in the validation cohorts, which revealed a greater separation between prognostic classes for all cohorts compared with the previous RTOG RPA model.The proposed RPA model highlights the impact of supramaximal versus total resections and incorporates clinical and molecular factors into survival stratification. The RPA model may improve the accuracy of assessing prognostic groups. |
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| DOI: | doi:10.1158/1078-0432.CCR-23-3845 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1158/1078-0432.CCR-23-3845 |
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| | DOI: https://doi.org/10.1158/1078-0432.CCR-23-3845 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 192785394X |
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| Verknüpfungen: | → Zeitschrift |
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Incorporating supramaximal resection into survival stratification of IDH-wildtype glioblastoma / Park, Yae Won [VerfasserIn]; 1 November 2024 (Online-Ressource)
