| |  Online-Ressource |
|---|
| Verfasst von: | Arslan, Aysenur [VerfasserIn]  |
|---|
| | Labuhn, Svenja [VerfasserIn] |
|---|
| | Sala, Elisa [VerfasserIn] |
|---|
| | Ringhoffer, Mark [VerfasserIn] |
|---|
| | Schetelig, Johannes [VerfasserIn] |
|---|
| | Schröder, Thomas [VerfasserIn] |
|---|
| | Bug, Gesine [VerfasserIn] |
|---|
| | Franke, Georg-Nikolaus [VerfasserIn] |
|---|
| | Stelljes, Matthias [VerfasserIn] |
|---|
| | Dreger, Peter [VerfasserIn] |
|---|
| | Zeiser, Robert [VerfasserIn] |
|---|
| | Teschner, Daniel [VerfasserIn] |
|---|
| | Bethge, Wolfgang [VerfasserIn] |
|---|
| | Eder, Matthias [VerfasserIn] |
|---|
| | Edinger, Matthias [VerfasserIn] |
|---|
| | Amann, Elisa Maria [VerfasserIn] |
|---|
| | Neuchel, Christine [VerfasserIn] |
|---|
| | Schmid-Möglich, Amelie [VerfasserIn] |
|---|
| | Schmeller, Sandra [VerfasserIn] |
|---|
| | Beyersmann, Jan [VerfasserIn] |
|---|
| | Schrezenmeier, Hubert [VerfasserIn] |
|---|
| | Mytilineos, Joannis [VerfasserIn] |
|---|
| | Kröger, Nicolaus [VerfasserIn] |
|---|
| | Fürst, Daniel [VerfasserIn] |
|---|
| Titel: | Outcomes of haploidentical transplants with PT-CY vs 10/10 MUD transplants with ATG in Germany |
|---|
| Verf.angabe: | Aysenur Arslan, Svenja Labuhn, Elisa Sala, Mark Ringhoffer, Johannes Schetelig, Thomas Schröder, Gesine Bug, Georg-Nikolaus Franke, Matthias Stelljes, Peter Dreger, Robert Zeiser, Daniel Teschner, Wolfgang Bethge, Matthias Eder, Matthias Edinger, Elisa Maria Amann, Christine Neuchel, Amelie Schmid-Möglich, Sandra Schmeller, Jan Beyersmann, Hubert Schrezenmeier, Joannis Mytilineos, Nicolaus Kröger, and Daniel Fürst, on behalf of the German Registry for Stem Cell Transplantation |
|---|
| E-Jahr: | 2024 |
|---|
| Jahr: | December 10 2024 |
|---|
| Umfang: | 10 S. |
|---|
| Illustrationen: | Illustrationen |
|---|
| Fussnoten: | Online veröffentlicht: 3. Dezember 2024 ; Gesehen am 10.06.2025 |
|---|
| Titel Quelle: | Enthalten in: Blood advances |
|---|
| Ort Quelle: | Washington, DC : American Society of Hematology, 2016 |
|---|
| Jahr Quelle: | 2024 |
|---|
| Band/Heft Quelle: | 8(2024), 23 vom: Dez., Seite 6104-6113 |
|---|
| ISSN Quelle: | 2473-9537 |
|---|
| Abstract: | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the best curative treatment modality for many malignant hematologic disorders. In the absence of a matched related donor, matched unrelated donors (MUDs) and haploidentical donors are the most important stem cell sources. In this registry-based retrospective study, we compared the outcomes of allo-HSCTs from 10/10 MUDs with antithymocyte globulin (ATG)-based regimens (n = 7050) vs haploidentical transplants (Haplo-Tx) using posttransplant cyclophosphamide (PT-CY Haplo; n = 487) in adult patients with hematologic malignancies between 2010 and 2020. Cox proportional hazard-and competing risks regression models were formed to compare the outcomes. Overall survival (OS), Disease-free survival (DFS), and graft-versus-host disease (GVHD)-free and relapse-free survival (GRFS) were superior for 10/10 MUDs (OS [hazard ratio (HR), 1.27; 95% confidence interval (CI), 1.10-1.47; P = .001]; DFS [HR, 1.17; CI, 1.02-1.34; P = .022]; GRFS [HR, 1.34; CI, 1.19-1.50; P < .001]). The risk of acute GVHD (aGVHD) grade 2 to 4, aGVHD grade 3 to 4, and chronic GVHD (cGVHD) was higher in the PT-CY Haplo group than the 10/10 MUD group (aGVHD grade 2-4 [HR, 1.46; CI, 1.25-1.71; P < .001]; aGVHD grade 3-4 [HR, 1.74; CI, 1.37- 2.20; P < .001]; cGVHD [HR, 1.30; CI, 1.11-1.51; P = .001]). A lower incidence of relapse was observed in the PT-CY Haplo group (relapse: HR, 0.83; CI, 0.69-0.99; P = .038). Unrelated 10/10 matched transplantation with ATG leads to lower GVHD rates and improved survival rates compared with PT-CY Haplo transplantation in Germany. |
|---|
| DOI: | doi:10.1182/bloodadvances.2024013719 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1182/bloodadvances.2024013719 |
|---|
| | DOI: https://doi.org/10.1182/bloodadvances.2024013719 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| K10plus-PPN: | 1927856736 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Outcomes of haploidentical transplants with PT-CY vs 10/10 MUD transplants with ATG in Germany / Arslan, Aysenur [VerfasserIn]; December 10 2024 (Online-Ressource)
