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Verfasst von:Hakenberg, Priska [VerfasserIn]   i
 Kalev, Georgi [VerfasserIn]   i
 Seyfried, Steffen [VerfasserIn]   i
 Reißfelder, Christoph [VerfasserIn]   i
 Hardt, Julia [VerfasserIn]   i
Titel:Recurrence patterns and management of locally recurrent rectal cancer
Titelzusatz:a retrospective cohort study$dresearch
Verf.angabe:P. Hakenberg, G. Kalev, S. Seyfried, C. Reißfelder, J. Hardt
E-Jahr:2025
Jahr:December 2025
Umfang:9 S.
Illustrationen:Diagramme
Fussnoten:Online veröffentlicht: 02. April 2025 ; Gesehen am 10.06.2025
Titel Quelle:Enthalten in: Langenbeck's archives of surgery
Ort Quelle:Berlin : Springer, 1998
Jahr Quelle:2025
Band/Heft Quelle:410(2025), 1 vom: Dez., Artikel-ID 116, Seite 1-9
ISSN Quelle:1435-2451
Abstract:Purpose Treatment of locally recurrent rectal cancer (LRRC) is still challenging because of inhomogeneous patient cohorts regarding previous treatments as well as different recurrence patterns and locations. The aim of this study was to investigate the treatments and surgical approaches tailored to them. Methods We included all patients who were treated for LRRC without distant metastasis at the University Medical Center Mannheim, Germany, between 2010 and 2021. We collected data from our electronic clinical data management system regarding the initial diagnosis and treatment, as well as the locations and treatment of the recurrent tumor. Results We identified a total of 666 patients who were curatively treated for rectal cancer of whom 36 patients (5.4%) developed LRRC without distant recurrence. Most patients (26/36) had a tailored therapy regimen that included surgery with or without perioperative radiation and/or chemotherapy. The most common site of local relapse was around the former colorectal anastomosis (15/36, 41.7%). The operative procedures ranged from anterior resection to multi-organ resection and exenteration. A complete resection (R0) could be achieved in twelve patients (12/22. 54.5%). The 3- and 5-year overall survival rates were 79% and 72%, respectively. Conclusion Most local recurrences occur at the anastomotic site and are mostly eligible for curative surgical therapy with good long-term survival.
DOI:doi:10.1007/s00423-025-03692-x
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1007/s00423-025-03692-x
 kostenfrei: Volltext: http://link.springer.com/article/10.1007/s00423-025-03692-x
 DOI: https://doi.org/10.1007/s00423-025-03692-x
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1927857333
Verknüpfungen:→ Zeitschrift

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