| |  Online-Ressource |
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| Verfasst von: | Sigaud, Romain [VerfasserIn]  |
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| | Brummer, Tilman [VerfasserIn] |
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| | Kocher, Daniela [VerfasserIn] |
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| | Milde, Till [VerfasserIn] |
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| | Selt, Florian [VerfasserIn] |
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| Titel: | MOST wanted |
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| Titelzusatz: | navigating the MAPK-OIS-SASP-tumor microenvironment axis in primary pediatric low-grade glioma and preclinical models |
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| Verf.angabe: | Romain Sigaud, Tilman Brummer, Daniela Kocher, Till Milde, Florian Selt |
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| E-Jahr: | 2024 |
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| Jahr: | October 2024 |
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| Umfang: | 13 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 25 May 2024 ; Gesehen am 10.06.2025 |
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| Titel Quelle: | Enthalten in: Child's nervous system |
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| Ort Quelle: | Berlin : Springer, 1985 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 40(2024), 10 vom: Okt., Seite 3209-3221 |
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| ISSN Quelle: | 1433-0350 |
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| Abstract: | Understanding the molecular and cellular mechanisms driving pediatric low-grade glioma (pLGG)-the most prevalent brain tumor in children-is essential for the identification and evaluation of novel effective treatments. This review explores the intricate relationship between the mitogen-activated protein kinase (MAPK) pathway, oncogene-induced senescence (OIS), the senescence-associated secretory phenotype (SASP), and the tumor microenvironment (TME), integrating these elements into a unified framework termed the MAPK/OIS/SASP/TME (MOST) axis. This integrated approach seeks to deepen our understanding of pLGG and improve therapeutic interventions by examining the MOST axis' critical influence on tumor biology and response to treatment. In this review, we assess the axis' capacity to integrate various biological processes, highlighting new targets for pLGG treatment, and the need for characterized in vitro and in vivo preclinical models recapitulating pLGG's complexity to test targets. The review underscores the need for a comprehensive strategy in pLGG research, positioning the MOST axis as a pivotal approach in understanding pLGG. This comprehensive framework will open promising avenues for patient care and guide future research towards inventive treatment options. |
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| DOI: | doi:10.1007/s00381-024-06463-z |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1007/s00381-024-06463-z |
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| | DOI: https://doi.org/10.1007/s00381-024-06463-z |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animals |
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| | Brain Neoplasms |
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| | Cellular Senescence |
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| | Child |
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| | Glioma |
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| | Humans |
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| | MAP Kinase Signaling System |
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| | MAPK pathway |
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| | Microenvironment |
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| | Oncogene-induced senescence |
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| | Pediatric low-grade glioma |
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| | Senescence-associated secretory phenotype |
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| | Tumor Microenvironment |
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| K10plus-PPN: | 1927892147 |
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| Verknüpfungen: | → Zeitschrift |
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