Central vs. brachial blood pressure and pulse pressure amplification for mortality risk prediction in patients undergoing coronary angiography

• Verfasst von: Daschner, Clara [VerfasserIn]
• Verfasst von: Kleber, Marcus E. [VerfasserIn]
• Verfasst von: Ayasse, Niklas [VerfasserIn]
• Verfasst von: Stach-Jablonski, Ksenija [VerfasserIn]
• Verfasst von: Yücel, Gökhan [VerfasserIn]
• Verfasst von: Husain-Syed, Faeq [VerfasserIn]
• Verfasst von: Niessner, Alexander [VerfasserIn]
• Verfasst von: Krüger, Bernd [VerfasserIn]
• Verfasst von: März, Winfried [VerfasserIn]
• Verfasst von: Krämer, Bernhard [VerfasserIn]
• Verfasst von: Yazdani, Babak [VerfasserIn]
• Titel: Central vs. brachial blood pressure and pulse pressure amplification for mortality risk prediction in patients undergoing coronary angiography
• Verf.angabe: Clara Daschner, Marcus E. Kleber, Niklas Ayasse, Ksenija Stach, Gökhan Yücel, Faeq Husain-Syed, Alexander Niessner, Bernd Krüger, Winfried März, Bernhard K. Krämer, and Babak Yazdani
• E-Jahr: 2025
• Jahr: May 2025
• Umfang: 8 S.
• Illustrationen: Illustrationen
• Fussnoten: Online veröffentlicht: 19. Dezember 2024 ; Gesehen am 11.06.2025
• Titel Quelle: Enthalten in: American journal of hypertension
• Ort Quelle: Oxford : Oxford Univ. Press, 1988
• Jahr Quelle: 2025
• Band/Heft Quelle: 38(2025), 5, Seite 272-279
• ISSN Quelle: 1941-7225
• DOI: doi:10.1093/ajh/hpae156
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1927941024

Abstract

Arterial hypertension is a significant risk factor for cardiovascular (CV) morbidity and mortality. Although central blood pressure (BP) evaluation is considered the gold standard, the reliability of non-invasive measurements remains unclear. Therefore, we compared the predictive value of invasively measured central BP with non-invasively measured brachial BP and analyzed pulse pressure (PP) amplification (delta-PP; the difference between central and peripheral PP) as an independent predictor of mortality.We analyzed systolic BP (SBP), diastolic BP (DBP), mean arterial BP (MAP), PP, and delta-PP as predictors of CV and all-cause mortality in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study, involving 3,316 patients referred for coronary angiography.All brachial BP parameters, except DBP, were significantly linked to all-cause and CV mortality in a univariate analysis. A 10 mm Hg increase in SBP, MAP, and PP corresponded to increased risks of all-cause (11%, 10%, and 19%) and CV mortality (11%, 11%, and 18%). Central SBP and PP showed similar, but numerically weaker, associations with increased risks of all-cause (5% and 10%) and CV mortality (4% and 8%). After adjusting for age, sex, body mass index, diabetes mellitus, and eGFR, only delta-PP independently predicted mortality with a 10 mm Hg increase linked to a 4% reduction in all causes and a 6% reduction in CV mortality.Neither brachial nor centrally measured BP parameters were independent mortality predictors in contrast to PP amplification, which remained an independent predictor of mortality in multivariate analysis, in a cohort with a medium to high CV risk profile. As PP amplification decreased, mortality increased.