| |  Online-Ressource |
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| Verfasst von: | Perrino, Melissa [VerfasserIn]  |
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| | Das, Anirban [VerfasserIn] |
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| | Scollon, Sarah R. [VerfasserIn] |
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| | Mitchell, Sarah G. [VerfasserIn] |
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| | Greer, Mary-Louise C. [VerfasserIn] |
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| | Yohe, Marielle E. [VerfasserIn] |
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| | Hansford, Jordan R. [VerfasserIn] |
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| | Kalish, Jennifer M. [VerfasserIn] |
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| | Schultz, Kris Ann P. [VerfasserIn] |
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| | MacFarland, Suzanne P. [VerfasserIn] |
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| | Kohlmann, Wendy K. [VerfasserIn] |
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| | Lupo, Philip J. [VerfasserIn] |
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| | Maxwell, Kara N. [VerfasserIn] |
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| | Pfister, Stefan [VerfasserIn] |
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| | Weksberg, Rosanna [VerfasserIn] |
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| | Michaeli, Orli [VerfasserIn] |
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| | Jongmans, Marjolijn C.J. [VerfasserIn] |
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| | Tomlinson, Gail E. [VerfasserIn] |
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| | Brzezinski, Jack [VerfasserIn] |
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| | Tabori, Uri [VerfasserIn] |
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| | Ney, Gina M. [VerfasserIn] |
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| | Gripp, Karen W. [VerfasserIn] |
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| | Gross, Andrea M. [VerfasserIn] |
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| | Widemann, Brigitte C. [VerfasserIn] |
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| | Stewart, Douglas R. [VerfasserIn] |
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| | Woodward, Emma R. [VerfasserIn] |
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| | Kratz, Christian P. [VerfasserIn] |
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| Titel: | Update on pediatric cancer surveillance recommendations for patients with Neurofibromatosis type 1, Noonan syndrome, CBL syndrome, Costello syndrome, and related RASopathies |
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| Verf.angabe: | Melissa R. Perrino, Anirban Das, Sarah R. Scollon, Sarah G. Mitchell, Mary-Louise C. Greer, Marielle E. Yohe, Jordan R. Hansford, Jennifer M. Kalish, Kris Ann P. Schultz, Suzanne P. MacFarland, Wendy K. Kohlmann, Philip J. Lupo, Kara N. Maxwell, Stefan M. Pfister, Rosanna Weksberg, Orli Michaeli, Marjolijn C.J. Jongmans, Gail E. Tomlinson, Jack Brzezinski, Uri Tabori, Gina M. Ney, Karen W. Gripp, Andrea M. Gross, Brigitte C. Widemann, Douglas R. Stewart, Emma R. Woodward, and Christian P. Kratz |
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| E-Jahr: | 2024 |
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| Jahr: | 1 November 2024 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 11.06.2025 |
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| Titel Quelle: | Enthalten in: Clinical cancer research |
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| Ort Quelle: | Philadelphia, Pa. [u.a.] : AACR, 1995 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 30(2024), 21 vom: Nov., Seite 4834-4843 |
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| ISSN Quelle: | 1557-3265 |
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| Abstract: | Neurofibromatosis type 1 (NF1), Noonan syndrome, and related syndromes, grouped as RASopathies, result from dysregulation of the RAS-MAPK pathway and demonstrate varied multisystemic clinical phenotypes. Together, RASopathies are among the more prevalent genetic cancer predisposition syndromes and require nuanced clinical management. When compared with the general population, children with RASopathies are at significantly increased risk of benign and malignant neoplasms. In the past decade, clinical trials have shown that targeted therapies can improve outcomes for low-grade and benign neoplastic lesions but have their own challenges, highlighting the multidisciplinary care needed for such individuals, specifically those with NF1. This perspective, which originated from the 2023 American Association for Cancer Research Childhood Cancer Predisposition Workshop, serves to update pediatric oncologists, neurologists, geneticists, counselors, and other health care professionals on revised diagnostic criteria, review previously published surveillance guidelines, and harmonize updated surveillance recommendations for patients with NF1 or RASopathies. |
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| DOI: | doi:10.1158/1078-0432.CCR-24-1611 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1158/1078-0432.CCR-24-1611 |
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| | DOI: https://doi.org/10.1158/1078-0432.CCR-24-1611 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1927945712 |
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| Verknüpfungen: | → Zeitschrift |
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Update on pediatric cancer surveillance recommendations for patients with Neurofibromatosis type 1, Noonan syndrome, CBL syndrome, Costello syndrome, and related RASopathies / Perrino, Melissa [VerfasserIn]; 1 November 2024 (Online-Ressource)
