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| Verfasst von: | Lütgendorf-Caucig, Carola [VerfasserIn]  |
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| | Wieland, Patricia [VerfasserIn] |
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| | Hug, Eugen [VerfasserIn] |
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| | Flechl, Birgit [VerfasserIn] |
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| | Tubin, Slavisa [VerfasserIn] |
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| | Galalae, Razvan [VerfasserIn] |
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| | Georg, Petra [VerfasserIn] |
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| | Fossati, Piero [VerfasserIn] |
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| | Mumot, Marta [VerfasserIn] |
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| | Harrabi, Semi B. [VerfasserIn] |
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| | Pradler, Irina [VerfasserIn] |
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| | Pelak, Maciej J. [VerfasserIn] |
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| Titel: | The value of PET/CT in particle therapy planning of various tumors with SSTR2 receptor expression |
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| Titelzusatz: | comparative interobserver study |
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| Verf.angabe: | Carola Lütgendorf-Caucig, Patricia Wieland, Eugen Hug, Birgit Flechl, Slavisa Tubin, Razvan Galalae, Petra Georg, Piero Fossati, Marta Mumot, Semi Harrabi, Irina Pradler and Maciej J. Pelak |
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| E-Jahr: | 2024 |
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| Jahr: | 15 May 2024 |
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| Umfang: | 10 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 11.06.2025 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 16(2024), 10, Artikel-ID 1877, Seite 1-10 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | The overexpression of somatostatin receptor type 2 (SSTR2) is a property of various tumor types. Hybrid imaging utilizing [68Ga]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) may improve the differentiation between tumor and healthy tissue. We conducted an experimental study on 47 anonymized patient cases including 30 meningiomas, 12 PitNET and 5 SBPGL. Four independent observers were instructed to contour the macroscopic tumor volume on planning MRI and then reassess their volumes with the additional information from DOTA-PET/CT. The conformity between observers and reference volumes was assessed. In total, 46 cases (97.9%) were DOTA-avid and included in the final analysis. In eight cases, PET/CT additional tumor volume was identified that was not detected by MRI; these PET/CT findings were potentially critical for the treatment plan in four cases. For meningiomas, the interobserver and observer to reference volume conformity indices were higher with PET/CT. For PitNET, the volumes had higher conformity between observers with MRI. With regard to SBGDL, no significant trend towards conformity with the addition of PET/CT information was observed. DOTA PET/CT supports accurate tumor recognition in meningioma and PitNET and is recommended in SSTR2-expressing tumors planned for treatment with highly conformal radiation. |
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| DOI: | doi:10.3390/cancers16101877 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/cancers16101877 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2072-6694/16/10/1877 |
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| | DOI: https://doi.org/10.3390/cancers16101877 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | contouring |
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| | DOTA |
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| | glomus tympanicum tumor |
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| | interobserver variability |
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| | meningioma |
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| | PET/CT |
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| | PitNET |
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| | proton therapy |
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| K10plus-PPN: | 1927980496 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ value of PET/CT in particle therapy planning of various tumors with SSTR2 receptor expression / Lütgendorf-Caucig, Carola [VerfasserIn]; 15 May 2024 (Online-Ressource)
