| |  Online-Ressource |
|---|
| Verfasst von: | Betzler, Alexander [VerfasserIn]  |
|---|
| | Betzler, Johanna [VerfasserIn] |
|---|
| | Bogner, Andreas [VerfasserIn] |
|---|
| | Walther, Elene [VerfasserIn] |
|---|
| | Rahbari, Mohammad [VerfasserIn] |
|---|
| | Reissfelder, Christoph [VerfasserIn] |
|---|
| | Riediger, Carina [VerfasserIn] |
|---|
| | Weitz, Jürgen [VerfasserIn] |
|---|
| | Rahbari, Nuh N. [VerfasserIn] |
|---|
| | Birgin, Emrullah [VerfasserIn] |
|---|
| Titel: | Long-term diuretic medication is an independent predictor of posthepatectomy liver failure |
|---|
| Verf.angabe: | Alexander Betzler, Johanna Betzler, Andreas Bogner, Elene Walther, Mohammad Rahbari, Christoph Reissfelder, Carina Riediger, Jürgen Weitz, Nuh N. Rahbari, Emrullah Birgin |
|---|
| E-Jahr: | 2025 |
|---|
| Jahr: | May 2025 |
|---|
| Umfang: | 6 S. |
|---|
| Illustrationen: | Illustrationen |
|---|
| Fussnoten: | Online verfügbar: 26. März 2025, Artikelversion: 4. April 2025 ; Gesehen am 12.06.2025 |
|---|
| Titel Quelle: | Enthalten in: Journal of gastrointestinal surgery |
|---|
| Ort Quelle: | [Amsterdam] : Elsevier, 1997 |
|---|
| Jahr Quelle: | 2025 |
|---|
| Band/Heft Quelle: | 29(2025), 5, Artikel-ID 102035, Seite 1-6 |
|---|
| ISSN Quelle: | 1873-4626 |
|---|
| Abstract: | Background - Posthepatectomy liver failure (PHLF) is the most fatal complication after liver resection, particularly in patients with comorbidities. This study aimed to assess the effect of long-term medication on PHLF incidence after open liver resections. - Methods - A retrospective analysis of 682 patients who underwent elective open hepatectomies between 2008 and 2015 at 2 academic centers was performed. Preoperative, intraoperative, and postoperative data were collected, including long-term medication. The risk factors for the development of PHLF and other postoperative complications were evaluated using univariate and multivariate logistic regression analyses. - Results - PHLF occurred in 81 patients (11.9%), with a higher incidence in patients taking diuretics as long-term medication than in those not taking diuretics (17.7% vs 5.3%, respectively; P <.001). Diuretic use was identified as a strong independent risk factor for PHLF (odds ratio [OR], 3.8 [95% CI, 2.1-7.0]; P <.001), alongside liver cirrhosis (OR, 3.8 [95% CI, 1.9-7.6]; P <.001), primary liver malignancies (OR, 3.8 [95% CI, 1.6-9.3]; P <.001), major hepatectomies (OR, 3.1 [95% CI, 1.7-5.7]; P <.001), and long operating time (OR, 4.2 [95% CI, 2.4-7.2]; P <.001). Patients with long-term diuretic intake were older, had higher body mass indices, and had more comorbidities, including liver cirrhosis. - Conclusion - Long-term diuretic use is associated with a significantly increased risk of PHLF after open hepatectomy. |
|---|
| DOI: | doi:10.1016/j.gassur.2025.102035 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.gassur.2025.102035 |
|---|
| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S1091255X25000940 |
|---|
| | DOI: https://doi.org/10.1016/j.gassur.2025.102035 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Comedication |
|---|
| | Hepatectomy |
|---|
| | International Study Group of Liver Surgery |
|---|
| | Liver insufficiency |
|---|
| | Multimorbidity |
|---|
| K10plus-PPN: | 1928064191 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Long-term diuretic medication is an independent predictor of posthepatectomy liver failure / Betzler, Alexander [VerfasserIn]; May 2025 (Online-Ressource)
