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Status: Bibliographieeintrag

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Verfasst von:Betzler, Alexander [VerfasserIn]   i
 Betzler, Johanna [VerfasserIn]   i
 Bogner, Andreas [VerfasserIn]   i
 Walther, Elene [VerfasserIn]   i
 Rahbari, Mohammad [VerfasserIn]   i
 Reissfelder, Christoph [VerfasserIn]   i
 Riediger, Carina [VerfasserIn]   i
 Weitz, Jürgen [VerfasserIn]   i
 Rahbari, Nuh N. [VerfasserIn]   i
 Birgin, Emrullah [VerfasserIn]   i
Titel:Long-term diuretic medication is an independent predictor of posthepatectomy liver failure
Verf.angabe:Alexander Betzler, Johanna Betzler, Andreas Bogner, Elene Walther, Mohammad Rahbari, Christoph Reissfelder, Carina Riediger, Jürgen Weitz, Nuh N. Rahbari, Emrullah Birgin
E-Jahr:2025
Jahr:May 2025
Umfang:6 S.
Illustrationen:Illustrationen
Fussnoten:Online verfügbar: 26. März 2025, Artikelversion: 4. April 2025 ; Gesehen am 12.06.2025
Titel Quelle:Enthalten in: Journal of gastrointestinal surgery
Ort Quelle:[Amsterdam] : Elsevier, 1997
Jahr Quelle:2025
Band/Heft Quelle:29(2025), 5, Artikel-ID 102035, Seite 1-6
ISSN Quelle:1873-4626
Abstract:Background - Posthepatectomy liver failure (PHLF) is the most fatal complication after liver resection, particularly in patients with comorbidities. This study aimed to assess the effect of long-term medication on PHLF incidence after open liver resections. - Methods - A retrospective analysis of 682 patients who underwent elective open hepatectomies between 2008 and 2015 at 2 academic centers was performed. Preoperative, intraoperative, and postoperative data were collected, including long-term medication. The risk factors for the development of PHLF and other postoperative complications were evaluated using univariate and multivariate logistic regression analyses. - Results - PHLF occurred in 81 patients (11.9%), with a higher incidence in patients taking diuretics as long-term medication than in those not taking diuretics (17.7% vs 5.3%, respectively; P <.001). Diuretic use was identified as a strong independent risk factor for PHLF (odds ratio [OR], 3.8 [95% CI, 2.1-7.0]; P <.001), alongside liver cirrhosis (OR, 3.8 [95% CI, 1.9-7.6]; P <.001), primary liver malignancies (OR, 3.8 [95% CI, 1.6-9.3]; P <.001), major hepatectomies (OR, 3.1 [95% CI, 1.7-5.7]; P <.001), and long operating time (OR, 4.2 [95% CI, 2.4-7.2]; P <.001). Patients with long-term diuretic intake were older, had higher body mass indices, and had more comorbidities, including liver cirrhosis. - Conclusion - Long-term diuretic use is associated with a significantly increased risk of PHLF after open hepatectomy.
DOI:doi:10.1016/j.gassur.2025.102035
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1016/j.gassur.2025.102035
 kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S1091255X25000940
 DOI: https://doi.org/10.1016/j.gassur.2025.102035
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Comedication
 Hepatectomy
 International Study Group of Liver Surgery
 Liver insufficiency
 Multimorbidity
K10plus-PPN:1928064191
Verknüpfungen:→ Zeitschrift

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