Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Ma, Shujuan [VerfasserIn]   i
 Zheng, Yixiang [VerfasserIn]   i
 Fang, Mingli [VerfasserIn]   i
 Xiong, Yiquan [VerfasserIn]   i
 Hu, Liang [VerfasserIn]   i
 Liu, Yvonne [VerfasserIn]   i
 Gong, Fei [VerfasserIn]   i
 Krämer, Bernhard [VerfasserIn]   i
 Lin, Ge [VerfasserIn]   i
 Hocher, Berthold [VerfasserIn]   i
Titel:COVID-19 vaccination and pregnancy-induced hypertension risk in women undergoing assisted reproduction
Titelzusatz:reproductive epidemiology
Verf.angabe:Shujuan Ma, Yixiang Zheng, Mingli Fang, Yiquan Xiong, Liang Hu, Yvonne Liu, Fei Gong, Bernhard K. Krämer, Ge Lin, and Berthold Hocher
E-Jahr:2025
Jahr:June 2025
Umfang:11 S.
Fussnoten:Online veröffentlicht: 11. April 2025 ; Gesehen am 12.06.2025
Titel Quelle:Enthalten in: Human reproduction
Ort Quelle:Oxford : Oxford Univ. Press, 1986
Jahr Quelle:2025
Band/Heft Quelle:40(2025), 6 vom: Juni, Seite 1173-1182
ISSN Quelle:1460-2350
Abstract:Does COVID-19 vaccination affect the risk of pregnancy-induced hypertension (PIH) in women undergoing ARTs, and does this risk differ based on vaccine type (inactivated vs recombinant) and timing relative to embryo transfer?Women who received inactivated COVID-19 vaccines before undergoing ART had a significantly increased risk of developing PIH, particularly when vaccinated with two or more doses or when embryo transfer occurred within 1 month of vaccination.COVID-19 vaccination during pregnancy reduces the risk of severe COVID-19 illness with no significant safety concerns for the mother or fetus. PIH is a common complication in ART pregnancies, particularly in older women and those with higher BMI, but the effects of different COVID-19 vaccine types on PIH risk in ART pregnancies remain unclear.A retrospective cohort study analyzing 3911 women undergoing ART after receiving COVID-19 vaccines. The study period spanned from 1 December 2020 to 30 September 2022.Participants were categorized based on COVID-19 vaccination status, vaccine type (inactivated vs recombinant), and the timing of vaccination relative to embryo transfer. The primary outcome was the development of PIH. Multivariate robust Poisson regression was used to assess the association between vaccination and PIH, while subgroup analyses explored the risk across variables like age, BMI, and embryo transfer type.Women vaccinated with an inactivated COVID-19 vaccine prior to embryo transfer had a significantly higher incidence of PIH compared to unvaccinated counterparts (relative risk [RR] = 1.45; 95% CI 1.10-1.92; P = 0.009). In contrast, recombinant vaccines did not show a significant association with increased PIH risk (RR = 1.19; 95% CI 0.69-2.05; P = 0.537). The risk was particularly pronounced among women receiving two or more doses of the inactivated vaccines and those who had embryo transfers within 1 month of vaccination. Subgroup analyses showed elevated PIH risk in women aged ≥30 years old, those with BMI ≥22 kg/m2, individuals with secondary infertility, and those undergoing cleavage-stage or fresh embryo transfers.The study’s retrospective design limits causal inference. The sample is from a single ethnic background, and familial hypertension history was not available, potentially introducing residual confounding.The study suggests that the type and timing of COVID-19 vaccination may influence PIH risk in ART pregnancies. These findings underscore the need for careful consideration of vaccination type and timing in ART protocols and highlight the importance of further prospective studies to validate these results before influencing clinical decision-making.This work was supported by the Hunan High-Level Talent Aggregation Project [2022RC4007]; the National Natural Science Foundation of China [72004148]; the Hunan Provincial Enterprise Joint Fund [2024JJ9093]; the Hunan Provincial Grant for Innovative Province Construction [2019SK4012]; the Deutschlandstipendium of the Charite; the non-restricted research grant of Boehringer Ingelheim Ltd.; and the Research Grant of CITIC-Xiangya [YNXM-202304, 202217]. The authors report no conflicts of interest.N/A.
DOI:doi:10.1093/humrep/deaf055
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1093/humrep/deaf055
 DOI: https://doi.org/10.1093/humrep/deaf055
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1928079350
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69355683   QR-Code
zum Seitenanfang