Sex differences in long-term survival and cancer incidence after ruptured abdominal aortic aneurysm repair

• Verfasst von: Epple, Jasmin [VerfasserIn]
• Verfasst von: Böckler, Dittmar [VerfasserIn]
• Verfasst von: Grundmann, Reinhart T. [VerfasserIn]
• Titel: Sex differences in long-term survival and cancer incidence after ruptured abdominal aortic aneurysm repair
• Verf.angabe: Jasmin Epple, Dittmar Böckler and Reinhart T. Grundmann
• E-Jahr: 2024
• Jahr: 18 November 2024
• Umfang: 10 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 12.06.2025
• Weitere Titel: Titel des special issue: Clinical Updates on the Aortic Aneurysm and Aortic Dissection
• Titel Quelle: Enthalten in: Journal of Clinical Medicine
• Ort Quelle: Basel : MDPI, 2012
• Jahr Quelle: 2024
• Band/Heft Quelle: 13(2024), 22, special issue, Artikel-ID 6934, Seite 1-10
• ISSN Quelle: 2077-0383
• DOI: doi:10.3390/jcm13226934
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: cancer incidence
• Sach-SW: gender
• Sach-SW: long-term outcome
• Sach-SW: octogenarians
• Sach-SW: ruptured abdominal aortic aneurysm
• K10plus-PPN: 1928095429

Abstract

Background: Long-term gender-specific survival and cancer incidence in patients with ruptured abdominal aortic aneurysm (rAAA) were investigated after endovascular (EVAR) and open repair (OAR). Methods: Data from 2933 patients (EVAR n = 1187, OAR n = 1746) from a health insurance company in Germany (men n = 2391, women n = 542) were analyzed. All patients were cancer-free in their history. Results: Perioperative mortality was significantly higher after OAR (42.6%) than after EVAR (21.2%; p < 0.001). Women had significantly higher in-hospital mortality (41.5%) than men (32.2%). Notably, the 5-year survival was 36.9% after OAR and 40.8% after EVAR (p < 0.001), and 40.7% in men and 29.1% in women (p < 0.001). Overall, 17.2% of EVAR and 14.6% of OAR patients had cancer at 5 years (p = 0.328). Cancer incidence did not differ significantly between men and women. Patients with cancer had a significantly less favorable outcome compared to patients with no cancer (p = 0.002). Treatment of rAAA was also indicated in octogenarians, with survival rates of 19.9% after 5 years and even 38.4% with perioperative deaths excluded. Conclusions: Cancer represents a significant risk factor for survival in patients with rAAA. These patients should be monitored during follow-up, particularly regarding the development of lung cancer.