Exploring the dynamics of messenger ribonucleoprotein-mediated translation repression

• Verfasst von: Meyer, Julia [VerfasserIn]
• Verfasst von: Payr, Marco [VerfasserIn]
• Verfasst von: Duss, Olivier [VerfasserIn]
• Verfasst von: Hennig, Janosch [VerfasserIn]
• Titel: Exploring the dynamics of messenger ribonucleoprotein-mediated translation repression
• Titelzusatz: review article
• Verf.angabe: Julia Meyer, Marco Payr, Olivier Duss and Janosch Hennig
• E-Jahr: 2024
• Jahr: December 2024
• Umfang: 13 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 17.06.2025
• Titel Quelle: Enthalten in: Biochemical Society (Großbritannien)Biochemical Society transactions
• Ort Quelle: London : Portland Press, 1973
• Jahr Quelle: 2024
• Band/Heft Quelle: 52(2024), 6 vom: Dez., Seite 2267-2279
• ISSN Quelle: 1470-8752
• DOI: doi:10.1042/BST20231240
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1928473393

Abstract

Translational control is crucial for well-balanced cellular function and viability of organisms. Different mechanisms have evolved to up- and down-regulate protein synthesis, including 3′ untranslated region (UTR)-mediated translation repression. RNA binding proteins or microRNAs interact with regulatory sequence elements located in the 3′ UTR and interfere most often with the rate-limiting initiation step of translation. Dysregulation of post-transcriptional gene expression leads to various kinds of diseases, emphasizing the significance of understanding the mechanisms of these processes. So far, only limited mechanistic details about kinetics and dynamics of translation regulation are understood. This mini-review focuses on 3′ UTR-mediated translational regulation mechanisms and demonstrates the potential of using single-molecule fluorescence-microscopy for kinetic and dynamic studies of translation regulation in vivo and in vitro.