Endobronchial ultrasound-based support vector machine model for differentiating between benign and malignant mediastinal and hilar lymph nodes

• Verfasst von: Hu, Wenjia [VerfasserIn]
• Verfasst von: Wen, Feifei [VerfasserIn]
• Verfasst von: Zhao, Mengyu [VerfasserIn]
• Verfasst von: Li, Xiangnan [VerfasserIn]
• Verfasst von: Luo, Peiyuan [VerfasserIn]
• Verfasst von: Jiang, Guancheng [VerfasserIn]
• Verfasst von: Yang, Huizhen [VerfasserIn]
• Verfasst von: Herth, Felix [VerfasserIn]
• Verfasst von: Zhang, Xiaoju [VerfasserIn]
• Verfasst von: Zhang, Quncheng [VerfasserIn]
• Titel: Endobronchial ultrasound-based support vector machine model for differentiating between benign and malignant mediastinal and hilar lymph nodes
• Verf.angabe: Wenjia Hu, Feifei Wen, Mengyu Zhao, Xiangnan Li, Peiyuan Luo, Guancheng Jiang, Huizhen Yang, Felix J.F. Herth, Xiaoju Zhang, Quncheng Zhang
• E-Jahr: 2024
• Jahr: November 2024
• Umfang: 11 S.
• Fussnoten: Online veröffentlicht: 22. Juli 2024 ; Gesehen am 18.06.2025
• Titel Quelle: Enthalten in: Respiration
• Ort Quelle: Basel : Karger, 1968
• Jahr Quelle: 2024
• Band/Heft Quelle: 103(2024), 11 vom: Nov., Seite 675-685
• ISSN Quelle: 1423-0356
• DOI: doi:10.1159/000540467
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1928521517

Abstract

Introduction: The aim of the study was to establish an ultrasonographic radiomics machine learning model based on endobronchial ultrasound (EBUS) to assist in diagnosing benign and malignant mediastinal and hilar lymph nodes (LNs). Methods: The clinical and ultrasonographic image data of 197 patients were retrospectively analyzed. The radiomics features extracted by EBUS-based radiomics were analyzed by the least absolute shrinkage and selection operator. Then, we used a support vector machine (SVM) algorithm to establish an EBUS-based radiomics model. A total of 205 lesions were randomly divided into training (n = 143) and validation (n = 62) groups. The diagnostic efficiency was evaluated by receiver operating characteristic (ROC) curve analysis. Results: A total of 13 stable radiomics features with non-zero coefficients were selected. The SVM model exhibited promising performance in both groups. In the training group, the SVM model achieved an ROC area under the curve (AUC) of 0.892 (95% CI: 0.885-0.899), with an accuracy of 85.3%, sensitivity of 93.2%, and specificity of 79.8%. In the validation group, the SVM model had an ROC AUC of 0.906 (95% CI: 0.890-0.923), an accuracy of 74.2%, a sensitivity of 70.3%, and a specificity of 74.1%. Conclusion: The EBUS-based radiomics model can be used to differentiate mediastinal and hilar benign and malignant LNs. The SVM model demonstrated excellent potential as a diagnostic tool in clinical practice.