| |  Online-Ressource |
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| Verfasst von: | Tauch, Saskia [VerfasserIn]  |
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| | Hey, Joschka [VerfasserIn] |
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| | Kast, Bettina [VerfasserIn] |
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| | Gengenbacher, Nicolas [VerfasserIn] |
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| | Weiß, Lena [VerfasserIn] |
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| | Sator-Schmitt, Melanie [VerfasserIn] |
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| | Lohr, Sabrina [VerfasserIn] |
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| | Brobeil, Alexander [VerfasserIn] |
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| | Schirmacher, Peter [VerfasserIn] |
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| | Utikal, Jochen [VerfasserIn] |
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| | Augustin, Hellmut [VerfasserIn] |
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| | Plass, Christoph [VerfasserIn] |
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| | Angel, Peter [VerfasserIn] |
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| Titel: | A unique signature for cancer-associated fibroblasts in melanoma metastases |
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| Verf.angabe: | Saskia Tauch, Joschka Hey, Bettina Kast, Nicolas Gengenbacher, Lena Weiß, Melanie Sator-Schmitt, Sabrina Lohr, Alexander Brobeil, Peter Schirmacher, Jochen Utikal, Hellmut G. Augustin, Christoph Plass, Peter Angel |
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| E-Jahr: | 2025 |
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| Jahr: | March 2025 |
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| Umfang: | 9 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online veröffentlicht: 9. Februar 2025 ; Gesehen am 18.06.2025 |
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| Titel Quelle: | Enthalten in: Pigment cell & melanoma research |
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| Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 2008 |
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| Jahr Quelle: | 2025 |
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| Band/Heft Quelle: | 38(2025), 2, Artikel-ID e70002, Seite 1-9 |
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| ISSN Quelle: | 1755-148X |
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| Abstract: | Cancer-associated fibroblasts (CAFs) represent a central cell population of the tumor microenvironment (TME). Recently, single-cell RNA-sequencing (scRNA-seq) analyses of primary tumors of different cancer entities yielded different classifications of CAF subsets underscoring the heterogeneity of CAFs within the TME. Here, we analyzed the transcriptional signatures of approximately 8400 CAFs and normal fibroblasts by scRNA-seq and compared genetic profiles of CAFs from murine melanoma primary tumors to CAFs from corresponding melanoma lung metastases. This revealed distinct subsets for primary tumor and metastasis-specific CAF populations, respectively. Combined with the spatial characterization of metastasis CAFs at the RNA and protein level, scRNA analyses indicate tumor-dependent crosstalk between neutrophils and CAFs, mediated via SAA3 and IL1b-related signaling pathways, which can be recapitulated in vitro. Analyzing tissue sections of human patient samples, this interaction was found to be present in human melanoma metastasis. Taken together, our data highlight unique characteristics of metastasis CAFs with potential therapeutic impact for melanoma metastasis. |
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| DOI: | doi:10.1111/pcmr.70002 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1111/pcmr.70002 |
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| | kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/pcmr.70002 |
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| | DOI: https://doi.org/10.1111/pcmr.70002 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | CAF |
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| | melanoma |
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| | metastasis |
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| | SAA |
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| | scRNA sequencing |
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| K10plus-PPN: | 1928526551 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ unique signature for cancer-associated fibroblasts in melanoma metastases / Tauch, Saskia [VerfasserIn]; March 2025 (Online-Ressource)
