| |  Online-Ressource |
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| Verfasst von: | Steichele, Mona [VerfasserIn]  |
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| | Sauermann, Lara [VerfasserIn] |
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| | Pan, Qin [VerfasserIn] |
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| | Moneer, Jasmin [VerfasserIn] |
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| | Porte, Alexandra de la [VerfasserIn] |
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| | Heß, Martin [VerfasserIn] |
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| | Mercker, Moritz [VerfasserIn] |
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| | Strube, Catharina [VerfasserIn] |
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| | Flaswinkel, Heinrich [VerfasserIn] |
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| | Jenewein, Marcell [VerfasserIn] |
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| | Böttger, Angelika [VerfasserIn] |
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| Titel: | Notch signaling mediates between two pattern-forming processes during head regeneration in Hydra |
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| Verf.angabe: | Mona Steichele, Lara Sauermann, Qin Pan, Jasmin Moneer, Alexandra de la Porte, Martin Heß, Moritz Mercker, Catharina Strube, Heinrich Flaswinkel, Marcell Jenewein, Angelika Böttger |
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| E-Jahr: | 2025 |
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| Jahr: | January 2025 |
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| Umfang: | 18 S. |
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| Illustrationen: | Illustrationen, Diagramme |
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| Fussnoten: | Online veröffentlicht: 12. November 2024 ; Gesehen am 18.06.2025 |
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| Titel Quelle: | Enthalten in: Life science alliance |
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| Ort Quelle: | Heidelberg : EMBO Press, 2018 |
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| Jahr Quelle: | 2025 |
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| Band/Heft Quelle: | 8(2025), 1 vom: Jan., Seite 1-18 |
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| ISSN Quelle: | 2575-1077 |
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| Abstract: | Hydra head regeneration consists of hypostome/organizer and tentacle development, and involves Notch and Wnt/β-catenin signaling. Notch inhibition blocks hypostome/organizer regeneration, but not the appearance of the tentacle tissue. β-Catenin inhibition blocks tentacle, but not hypostome/organizer regeneration. Gene expression analyses during head regeneration revealed the Notch-promoting expression of HyWnt3, HyBMP2/4, and the transcriptional repressor genes CnGsc, Sp5, and HyHes, while blocking HyBMP5/8b and the c-fos-related gene HyKayak. β-Catenin promotes the expression of the tentacle specification factor HyAlx, but not of HyWnt3. This suggests HyWnt3 and HyBMP4 as parts of a hypostome/organizer gene module, and BMP5/8, HyAlx, and β-catenin as parts of a tentacle gene module. Notch then functions as an inhibitor of tentacle production to allow regeneration of a hypostome/head organizer. HyKayak is a candidate target gene for HvNotch-induced repressor genes. Inhibiting HyKayak attenuated the expression of HyWnt3. Polyps of Craspedacusta do not have tentacles and thus after head removal only regenerate a hypostome structure. Notch signaling was not needed for head regeneration in Craspedacusta, corroborating the idea of its requirement during Hydra head regeneration to harmonize two co-operating pattern-forming processes. |
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| DOI: | doi:10.26508/lsa.202403054 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.26508/lsa.202403054 |
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| | Volltext: https://www.life-science-alliance.org/content/8/1/e202403054 |
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| | DOI: https://doi.org/10.26508/lsa.202403054 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1928543243 |
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| Verknüpfungen: | → Zeitschrift |
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Notch signaling mediates between two pattern-forming processes during head regeneration in Hydra / Steichele, Mona [VerfasserIn]; January 2025 (Online-Ressource)
