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| Verfasst von: | Seum, Teresa [VerfasserIn]  |
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| | Niedermaier, Tobias [VerfasserIn] |
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| | Heisser, Thomas [VerfasserIn] |
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| | Hoffmeister, Michael [VerfasserIn] |
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| | Brenner, Hermann [VerfasserIn] |
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| Titel: | Next-generation multitarget stool DNA vs fecal immunochemical test in colorectal cancer screening |
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| Verf.angabe: | Teresa Seum, MSc, Tobias Niedermaier, PhD, Thomas Heisser, PhD, Michael Hoffmeister, PhD, Hermann Brenner, MD, MPH |
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| E-Jahr: | 2025 |
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| Jahr: | January 2025 |
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| Umfang: | 3 S. |
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| Fussnoten: | Online veröffentlicht: November 18, 2024 ; Gesehen am 27.06.2025 |
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| Titel Quelle: | Enthalten in: JAMA internal medicine |
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| Ort Quelle: | Chicago, Ill. : American Medical Association, 2013 |
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| Jahr Quelle: | 2025 |
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| Band/Heft Quelle: | 185(2025), 1 vom: Jan., Seite 110-112 |
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| ISSN Quelle: | 2168-6114 |
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| Abstract: | Fecal immunochemical tests (FITs) are the most widely used noninvasive colorectal cancer (CRC) screening tests. In 2014, a US/Canadian screening study reported higher sensitivity of a multitarget stool DNA test (MSDT), which combined fecal hemoglobin measurement with molecular DNA markers, compared with a commercial FIT. However, this increase in sensitivity was accompanied by a substantial loss of specificity. Despite 20-fold higher per-sample costs, use of MSDT-based screening strongly increased in the US in recent years. Recently, Imperiale et al evaluated diagnostic performance of a next-generation MSDT (NG-MSDT) in another screening colonoscopy cohort (BLUE-C study). Sensitivity was higher than that of a commercial FIT, although again specificity was lower. It was previously shown that lowering the positivity threshold of a commercial quantitative FIT could enhance diagnostic performance to be comparable to a multitarget stool ribonucleic acid (RNA) test, prompting an evaluation of whether the same approach could yield similar outcomes with the NG-MSDT. |
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| DOI: | doi:10.1001/jamainternmed.2024.6149 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1001/jamainternmed.2024.6149 |
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| | DOI: https://doi.org/10.1001/jamainternmed.2024.6149 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1929237529 |
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| Verknüpfungen: | → Zeitschrift |
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Next-generation multitarget stool DNA vs fecal immunochemical test in colorectal cancer screening / Seum, Teresa [VerfasserIn]; January 2025 (Online-Ressource)
