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| Verfasst von: | Terheyden, Jan H. [VerfasserIn]  |
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| | Dunbar, Hannah M. P. [VerfasserIn] |
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| | Schmitz-Valckenberg, Steffen [VerfasserIn] |
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| | Behning, Charlotte [VerfasserIn] |
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| | Martinho, Cecília [VerfasserIn] |
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| | Luhmann, Ulrich F. O. [VerfasserIn] |
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| | Saßmannshausen, Marlene [VerfasserIn] |
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| | Lüning, Anna [VerfasserIn] |
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| | Miliu, Alexandra [VerfasserIn] |
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| | Aires, Inês Dinis [VerfasserIn] |
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| | Basile, Pier Giorgio [VerfasserIn] |
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| | Batuca, Joana [VerfasserIn] |
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| | Schmid, Matthias [VerfasserIn] |
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| | Moll, Klaus-Peter [VerfasserIn] |
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| | Zakaria, Nadia [VerfasserIn] |
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| | Tufail, Adnan [VerfasserIn] |
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| | Binns, Alison [VerfasserIn] |
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| | Crabb, David P. [VerfasserIn] |
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| | Leal, Sergio [VerfasserIn] |
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| | Finger, Robert P. [VerfasserIn] |
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| | Holz, Frank G. [VerfasserIn] |
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| Titel: | Validating candidate endpoints for intermediate age-related macular degeneration trials in a multi-centre setting |
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| Titelzusatz: | lessons from the MACUSTAR study |
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| Verf.angabe: | Jan Henrik Terheyden, Hannah M.P. Dunbar, Steffen Schmitz-Valckenberg, Charlotte Behning, Cecília Martinho, Ulrich F.O. Luhmann, Marlene Saßmannshausen, Anna Lüning, Alexandra Miliu, Inês Dinis Aires, Pier Giorgio Basile, Joana Batuca, Matthias Schmid, Klaus-Peter Moll, Nadia Zakaria, Adnan Tufail, Alison Binns, David P. Crabb, Sergio Leal, Robert P. Finger, Frank G. Holz and on behalf of the MACUSTAR consortium |
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| E-Jahr: | 2025 |
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| Jahr: | 05 February 2025 |
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| Umfang: | 9 S. |
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| Illustrationen: | Illustrationen, Diagramme |
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| Fussnoten: | Gesehen am 01.07.2025 ; Mitglieder des MACUSTAR CONSORTIUM: H. Agostini, I.D. Aires, L. Altay, R. Atia, F. Bandello, P.G. Basile, J. Batuca, C. Behning, M. Belmouhand, M. Berger, A. Binns, C.J.F. Boon, M. Böttger, J.E. Brazier, C. Carapezzi, J. Carlton, A. Carneiro, A. Charil, R. Coimbra, D. Cosette, M. Cozzi, D.P. Crabb, J. Cunha-Vaz, C. Dahlke, H. Dunbar, R.P. Finger, E. Fletcher, M. Gutfleisch, F. Hartgers, B. Higgins, J. Hildebrandt, E. Höck, R. Hogg, F.G. Holz, C.B. Hoyng, A. Kilani, J. Krätzschmar, L. Kühlewein, M. Larsen, S. Leal, Y.T.E. Lechanteur, D. Lu, U.F.O. Luhmann, A. Lüning, N. Manivannan, I. Marques, C. Martinho, A. Miliu, K.P. Moll, Z. Mulyukov, M. Paques, B. Parodi, M. Parravano, S. Penas, T. Peters, T. Peto, S. Priglinger, R. Ramamirtham, R. Ribeiro, D. Rowen, G.S. Rubin, J. Sahel, C. Sánchez, O. Sander, M. Saßmannshausen, M. Schmid, S. Schmitz-Valckenberg, J. Siedlecki, R. Silva, E. Souied, G. Staurenghi, J. Tavares, D.J. Taylor, J.H. Terheyden, A. Tufail, P. Valmaggia, M. Varano, A. Wolf and N. Zakaria |
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| Titel Quelle: | Enthalten in: Eye |
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| Ort Quelle: | Basingstoke : Nature Publishing Group, 1987 |
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| Jahr Quelle: | 2025 |
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| Band/Heft Quelle: | 39(2025), 6, Seite 1031-1039 |
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| ISSN Quelle: | 1476-5454 |
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| Abstract: | For the conduct of future interventional age-related macular degeneration (AMD) trials, the availability of clinical study endpoints is key. However, no endpoints have been accepted by regulators for evaluation of treatment for intermediate (i) AMD, i.e. the AMD stage at highest risk of developing irreversible geographic atrophy or macular neovascularization. The European MACUSTAR consortium has recruited more than 700 individuals to develop and validate structural, functional and patient-reported endpoints, enabling future iAMD trials based on a prospective observational, multi-centre cohort study. Reliably assessing candidate endpoints in a setting that involves multiple clinical sites across countries comes with a plurality of challenges in the study set-up, quality of data, recruitment of participants and study conduct. Therefore, the MACUSTAR consortium has established a framework that successfully addresses these topics, provides relevant insights into the natural history of iAMD and its sub-phenotypes, and will open new regulatory pathways. The MACUSTAR study is registered on ClinicalTrials.gov under NCT03349801. |
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| DOI: | doi:10.1038/s41433-024-03568-2 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41433-024-03568-2 |
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| | kostenfrei: Volltext: http://www.nature.com/articles/s41433-024-03568-2 |
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| | DOI: https://doi.org/10.1038/s41433-024-03568-2 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Prognostic markers |
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| | Retinal diseases |
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| K10plus-PPN: | 1929395639 |
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| Verknüpfungen: | → Zeitschrift |
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Validating candidate endpoints for intermediate age-related macular degeneration trials in a multi-centre setting / Terheyden, Jan H. [VerfasserIn]; 05 February 2025 (Online-Ressource)
