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| Verfasst von: | Melzer, Thomas [VerfasserIn]  |
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| | Graf, Veronika [VerfasserIn] |
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| | Kronseder, Angelika [VerfasserIn] |
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| | Karrasch, Stefan [VerfasserIn] |
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| | Kerschner, Martina [VerfasserIn] |
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| | Vogelmeier, Claus F. [VerfasserIn] |
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| | Bals, Robert [VerfasserIn] |
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| | Alter, Peter [VerfasserIn] |
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| | Watz, Henrik [VerfasserIn] |
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| | Fähndrich, Sebastian [VerfasserIn] |
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| | Behr, Jürgen [VerfasserIn] |
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| | Waschki, Benjamin [VerfasserIn] |
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| | Trudzinski, Franziska [VerfasserIn] |
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| | Jörres, Rudolf A. [VerfasserIn] |
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| | Kahnert, Kathrin [VerfasserIn] |
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| Titel: | Skin markers of premature ageing in patients with COPD |
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| Titelzusatz: | results form COSYCONET |
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| Verf.angabe: | Thomas Melzer, Veronika Graf, Angelika Kronseder, Stefan Karrasch, Martina Kerschner, Claus F. Vogelmeier, Robert Bals, Peter Alter, Henrik Watz, Sebastian Fähndrich, Jürgen Behr, Benjamin Waschki, Franziska Christina Trudzinski, Rudolf A. Jörres and Kathrin Kahnert |
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| E-Jahr: | 2024 |
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| Jahr: | 19 November 2024 |
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| Umfang: | 14 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 07.07.2025 |
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| Titel Quelle: | Enthalten in: Journal of Clinical Medicine |
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| Ort Quelle: | Basel : MDPI, 2012 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 13(2024), 22, Artikel-ID 6972, Seite 1-14 |
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| ISSN Quelle: | 2077-0383 |
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| Abstract: | Background: Chronic obstructive pulmonary disease (COPD) is commonly associated with ageing, with the prevalence and severity increasing by age. Smoking-induced premature ageing is thought to contribute to COPD, particularly lung emphysema. This study aimed to explore the relationship between lung function impairment and skin texture, as a marker of biological or premature ageing, in COPD patients. Methods: A subcohort from the COSYCONET COPD-study was analyzed, where skin-relief replicas of the eye’s outer corner and mid-lower inner arm were collected, along with semi-quantitative facial photographs. We examined the correlation between skin parameters and lung function, particularly the diffusing capacity (TLCO) as an indicator of emphysema. Results: Among 46 COPD patients (69 ± 8 years, 52% female), skin texture from the inner forearm, but not from the eye corner, was significantly associated with TLCO% predicted, with a higher skin roughness correlating with a lower TLCO (p = 0.015). This relationship persisted after adjusting for age, BMI, sex, pack years, and smoking status. No significant associations were found with facial photographs. Conclusions: These findings suggest that systemic ageing, reflected in inner arm skin texture, is linked to lung emphysema. Skin ageing markers may be valuable in future interventional studies involving anti-ageing treatments. |
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| DOI: | doi:10.3390/jcm13226972 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/jcm13226972 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2077-0383/13/22/6972 |
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| | DOI: https://doi.org/10.3390/jcm13226972 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | age-related diseases |
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| | COPD |
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| | emphysema |
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| | exposome |
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| | skin wrinkles |
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| K10plus-PPN: | 1929825900 |
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| Verknüpfungen: | → Zeitschrift |
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Skin markers of premature ageing in patients with COPD / Melzer, Thomas [VerfasserIn]; 19 November 2024 (Online-Ressource)
