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| Verfasst von: | Chih, Yu-Chan [VerfasserIn]  |
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| | Dietsch, Amelie C. [VerfasserIn] |
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| | Koopmann, Philipp [VerfasserIn] |
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| | Ma, Xiujian [VerfasserIn] |
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| | Agardy, Dennis [VerfasserIn] |
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| | Zhao, Binghao [VerfasserIn] |
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| | De Roia, Alice [VerfasserIn] |
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| | Kourtesakis, Alexandros [VerfasserIn] |
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| | Kilian, Michael [VerfasserIn] |
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| | Krämer, Christopher [VerfasserIn] |
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| | Suwala, Abigail Kora [VerfasserIn] |
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| | Stenzinger, Miriam [VerfasserIn] |
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| | Boenig, Halvard [VerfasserIn] |
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| | Blum, Agnieszka [VerfasserIn] |
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| | Pienkowski, Victor Murcia [VerfasserIn] |
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| | Aman, Kuralay [VerfasserIn] |
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| | Becker, Jonas Philipp [VerfasserIn] |
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| | Feldmann, Henrike [VerfasserIn] |
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| | Bunse, Theresa [VerfasserIn] |
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| | Harbottle, Richard P. [VerfasserIn] |
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| | Riemer, Angelika [VerfasserIn] |
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| | Liu, Hai-Kun [VerfasserIn] |
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| | Etminan, Nima [VerfasserIn] |
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| | Sahm, Felix [VerfasserIn] |
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| | Ratliff, Miriam [VerfasserIn] |
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| | Wick, Wolfgang [VerfasserIn] |
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| | Platten, Michael [VerfasserIn] |
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| | Green, Edward W. [VerfasserIn] |
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| | Bunse, Lukas [VerfasserIn] |
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| Titel: | Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen |
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| Verf.angabe: | Yu-Chan Chih, Amelie C. Dietsch, Philipp Koopmann, Xiujian Ma, Dennis A. Agardy, Binghao Zhao, Alice De Roia, Alexandros Kourtesakis, Michael Kilian, Christopher Krämer, Abigail K. Suwala, Miriam Stenzinger, Halvard Boenig, Agnieszka Blum, Victor Murcia Pienkowski, Kuralay Aman, Jonas P. Becker, Henrike Feldmann, Theresa Bunse, Richard Harbottle, Angelika B. Riemer, Hai-Kun Liu, Nima Etminan, Felix Sahm, Miriam Ratliff, Wolfgang Wick, Michael Platten, Edward W. Green and Lukas Bunse |
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| E-Jahr: | 2025 |
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| Jahr: | 01 February 2025 |
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| Umfang: | 16 S. |
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| Illustrationen: | Illustrationen, Diagramme |
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| Fussnoten: | Gesehen am 08.07.2025 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2025 |
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| Band/Heft Quelle: | 16(2025), Artikel-ID 1262, Seite 1-16 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | T cell receptor-engineered T cells (TCR-T) could be advantageous in glioblastoma by allowing safe and ubiquitous targeting of the glioblastoma-derived peptidome. Protein tyrosine phosphatase receptor type Z1 (PTPRZ1), is a clinically targetable glioblastoma antigen associated with glioblastoma cell stemness. Here, we identify a therapeutic HLA-A*02-restricted PTPRZ1-reactive TCR retrieved from a vaccinated glioblastoma patient. Single-cell sequencing of primary brain tumors shows PTPRZ1 overexpression in malignant cells, especially in glioblastoma stem cells (GSCs) and astrocyte-like cells. The validated vaccine-induced TCR recognizes the endogenously processed antigen without off-target cross-reactivity. PTPRZ1-specific TCR-T (PTPRZ1-TCR-T) kill target cells antigen-specifically, and in murine experimental brain tumors, their combined intravenous and intracerebroventricular administration is efficacious. PTPRZ1-TCR-T maintain stem cell memory phenotype in vitro and in vivo and lyse all examined HLA-A*02+ primary glioblastoma cell lines with a preference for GSCs and astrocyte-like cells. In summary, we demonstrate the proof of principle to employ TCR-T to treat glioblastoma. |
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| DOI: | doi:10.1038/s41467-025-56547-w |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41467-025-56547-w |
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| | kostenfrei: Volltext: http://www.nature.com/articles/s41467-025-56547-w |
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| | DOI: https://doi.org/10.1038/s41467-025-56547-w |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | CNS cancer |
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| | Cytotoxic T cells |
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| | Immunological memory |
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| | Immunotherapy |
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| K10plus-PPN: | 1929925794 |
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| Verknüpfungen: | → Zeitschrift |
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Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen / Chih, Yu-Chan [VerfasserIn]; 01 February 2025 (Online-Ressource)
