| Online-Ressource |
Verfasst von: | Rößner, Philipp M. [VerfasserIn]  |
| Seufert, Isabelle [VerfasserIn]  |
| Chapaprieta, Vicente [VerfasserIn]  |
| Jayabalan, Ruparoshni [VerfasserIn]  |
| Briesch, Hannah [VerfasserIn]  |
| Massoni-Badosa, Ramon [VerfasserIn]  |
| Boskovic, Pavle [VerfasserIn]  |
| Benckendorff, Julian [VerfasserIn]  |
| Roider, Tobias [VerfasserIn]  |
| Arseni, Lavinia [VerfasserIn]  |
| Coelho, Mariana [VerfasserIn]  |
| Chakraborty, Supriya [VerfasserIn]  |
| Vaca, Alicia M. [VerfasserIn]  |
| Sivina, Mariela [VerfasserIn]  |
| Muckenhuber, Markus [VerfasserIn]  |
| Rodriguez-Rodriguez, Sonia [VerfasserIn]  |
| Bonato, Alice [VerfasserIn]  |
| Herbst, Sophie A. [VerfasserIn]  |
| Zapatka, Marc [VerfasserIn]  |
| Sun, Clare [VerfasserIn]  |
| Kretzmer, Helene [VerfasserIn]  |
| Naake, Thomas [VerfasserIn]  |
| Bruch, Peter-Martin [VerfasserIn]  |
| Czernilofsky, Felix [VerfasserIn]  |
| ten Hacken, Elisa [VerfasserIn]  |
| Schneider, Martin [VerfasserIn]  |
| Helm, Dominic [VerfasserIn]  |
| Yosifov, Deyan Y. [VerfasserIn]  |
| Kauer, Joseph [VerfasserIn]  |
| Danilov, Alexey V. [VerfasserIn]  |
| Bewarder, Moritz [VerfasserIn]  |
| Heyne, Kristina [VerfasserIn]  |
| Schneider, Christof [VerfasserIn]  |
| Stilgenbauer, Stephan [VerfasserIn]  |
| Wiestner, Adrian [VerfasserIn]  |
| Mallm, Jan-Philipp [VerfasserIn]  |
| Burger, Jan A. [VerfasserIn]  |
| Efremov, Dimitar G. [VerfasserIn]  |
| Lichter, Peter [VerfasserIn]  |
| Dietrich, Sascha [VerfasserIn]  |
| Martin-Subero, José I. [VerfasserIn]  |
| Rippe, Karsten [VerfasserIn]  |
| Seiffert, Martina [VerfasserIn]  |
Titel: | T-bet suppresses proliferation of malignant B cells in chronic lymphocytic leukemia |
Verf.angabe: | Philipp M. Roessner, Isabelle Seufert, Vicente Chapaprieta, Ruparoshni Jayabalan, Hannah Briesch, Ramon Massoni-Badosa, Pavle Boskovic, Julian Benckendorff, Tobias Roider, Lavinia Arseni, Mariana Coelho, Supriya Chakraborty, Alicia M. Vaca, Mariela Sivina, Markus Muckenhuber, Sonia Rodriguez-Rodriguez, Alice Bonato, Sophie A. Herbst, Marc Zapatka, Clare Sun, Helene Kretzmer, Thomas Naake, Peter-Martin Bruch, Felix Czernilofsky, Elisa ten Hacken, Martin Schneider, Dominic Helm, Deyan Y. Yosifov, Joseph Kauer, Alexey V. Danilov, Moritz Bewarder, Kristina Heyne, Christof Schneider, Stephan Stilgenbauer, Adrian Wiestner, Jan-Philipp Mallm, Jan A. Burger, Dimitar G. Efremov, Peter Lichter, Sascha Dietrich, José I. Martin-Subero, Karsten Rippe, Martina Seiffert |
E-Jahr: | 2024 |
Jahr: | August 1 2024 |
Umfang: | 15 S. |
Fussnoten: | Gesehen am 10.07.2025 |
Titel Quelle: | Enthalten in: Blood |
Ort Quelle: | Washington, DC : American Society of Hematology, 1946 |
Jahr Quelle: | 2024 |
Band/Heft Quelle: | 144(2024), 5 vom: Aug., Seite 510-524 |
ISSN Quelle: | 1528-0020 |
Abstract: | The T-box transcription factor T-bet is known as a master regulator of the T-cell response but its role in malignant B cells has not been sufficiently explored. Here, we conducted single-cell resolved multi-omics analyses of malignant B cells from patients with chronic lymphocytic leukemia (CLL) and studied a CLL mouse model with a genetic knockout of Tbx21. We found that T-bet acts as a tumor suppressor in malignant B cells by decreasing their proliferation rate. NF-κB activity, induced by inflammatory signals provided by the microenvironment, triggered T-bet expression, which affected promoter-proximal and distal chromatin coaccessibility and controlled a specific gene signature by mainly suppressing transcription. Gene set enrichment analysis identified a positive regulation of interferon signaling and negative control of proliferation by T-bet. In line, we showed that T-bet represses cell cycling and is associated with longer overall survival of patients with CLL. Our study uncovered a novel tumor suppressive role of T-bet in malignant B cells via its regulation of inflammatory processes and cell cycling, which has implications for the stratification and therapy of patients with CLL. Linking T-bet activity to inflammation explains the good prognostic role of genetic alterations in the inflammatory signaling pathways in CLL. |
DOI: | doi:10.1182/blood.2023021990 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1182/blood.2023021990 |
| DOI: https://doi.org/10.1182/blood.2023021990 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1930142196 |
Verknüpfungen: | → Zeitschrift |
T-bet suppresses proliferation of malignant B cells in chronic lymphocytic leukemia / Rößner, Philipp M. [VerfasserIn]; August 1 2024 (Online-Ressource)