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| Verfasst von: | Rößner, Philipp M. [VerfasserIn]  |
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| | Seufert, Isabelle [VerfasserIn] |
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| | Chapaprieta, Vicente [VerfasserIn] |
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| | Jayabalan, Ruparoshni [VerfasserIn] |
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| | Briesch, Hannah [VerfasserIn] |
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| | Massoni-Badosa, Ramon [VerfasserIn] |
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| | Boskovic, Pavle [VerfasserIn] |
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| | Benckendorff, Julian [VerfasserIn] |
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| | Roider, Tobias [VerfasserIn] |
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| | Arseni, Lavinia [VerfasserIn] |
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| | Coelho, Mariana [VerfasserIn] |
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| | Chakraborty, Supriya [VerfasserIn] |
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| | Vaca, Alicia M. [VerfasserIn] |
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| | Sivina, Mariela [VerfasserIn] |
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| | Muckenhuber, Markus [VerfasserIn] |
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| | Rodriguez-Rodriguez, Sonia [VerfasserIn] |
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| | Bonato, Alice [VerfasserIn] |
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| | Herbst, Sophie A. [VerfasserIn] |
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| | Zapatka, Marc [VerfasserIn] |
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| | Sun, Clare [VerfasserIn] |
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| | Kretzmer, Helene [VerfasserIn] |
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| | Naake, Thomas [VerfasserIn] |
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| | Bruch, Peter-Martin [VerfasserIn] |
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| | Czernilofsky, Felix [VerfasserIn] |
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| | ten Hacken, Elisa [VerfasserIn] |
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| | Schneider, Martin [VerfasserIn] |
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| | Helm, Dominic [VerfasserIn] |
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| | Yosifov, Deyan Y. [VerfasserIn] |
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| | Kauer, Joseph [VerfasserIn] |
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| | Danilov, Alexey V. [VerfasserIn] |
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| | Bewarder, Moritz [VerfasserIn] |
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| | Heyne, Kristina [VerfasserIn] |
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| | Schneider, Christof [VerfasserIn] |
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| | Stilgenbauer, Stephan [VerfasserIn] |
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| | Wiestner, Adrian [VerfasserIn] |
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| | Mallm, Jan-Philipp [VerfasserIn] |
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| | Burger, Jan A. [VerfasserIn] |
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| | Efremov, Dimitar G. [VerfasserIn] |
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| | Lichter, Peter [VerfasserIn] |
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| | Dietrich, Sascha [VerfasserIn] |
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| | Martin-Subero, José I. [VerfasserIn] |
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| | Rippe, Karsten [VerfasserIn] |
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| | Seiffert, Martina [VerfasserIn] |
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| Titel: | T-bet suppresses proliferation of malignant B cells in chronic lymphocytic leukemia |
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| Verf.angabe: | Philipp M. Roessner, Isabelle Seufert, Vicente Chapaprieta, Ruparoshni Jayabalan, Hannah Briesch, Ramon Massoni-Badosa, Pavle Boskovic, Julian Benckendorff, Tobias Roider, Lavinia Arseni, Mariana Coelho, Supriya Chakraborty, Alicia M. Vaca, Mariela Sivina, Markus Muckenhuber, Sonia Rodriguez-Rodriguez, Alice Bonato, Sophie A. Herbst, Marc Zapatka, Clare Sun, Helene Kretzmer, Thomas Naake, Peter-Martin Bruch, Felix Czernilofsky, Elisa ten Hacken, Martin Schneider, Dominic Helm, Deyan Y. Yosifov, Joseph Kauer, Alexey V. Danilov, Moritz Bewarder, Kristina Heyne, Christof Schneider, Stephan Stilgenbauer, Adrian Wiestner, Jan-Philipp Mallm, Jan A. Burger, Dimitar G. Efremov, Peter Lichter, Sascha Dietrich, José I. Martin-Subero, Karsten Rippe, Martina Seiffert |
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| E-Jahr: | 2024 |
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| Jahr: | August 1 2024 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 10.07.2025 |
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| Titel Quelle: | Enthalten in: Blood |
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| Ort Quelle: | Washington, DC : American Society of Hematology, 1946 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 144(2024), 5 vom: Aug., Seite 510-524 |
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| ISSN Quelle: | 1528-0020 |
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| Abstract: | The T-box transcription factor T-bet is known as a master regulator of the T-cell response but its role in malignant B cells has not been sufficiently explored. Here, we conducted single-cell resolved multi-omics analyses of malignant B cells from patients with chronic lymphocytic leukemia (CLL) and studied a CLL mouse model with a genetic knockout of Tbx21. We found that T-bet acts as a tumor suppressor in malignant B cells by decreasing their proliferation rate. NF-κB activity, induced by inflammatory signals provided by the microenvironment, triggered T-bet expression, which affected promoter-proximal and distal chromatin coaccessibility and controlled a specific gene signature by mainly suppressing transcription. Gene set enrichment analysis identified a positive regulation of interferon signaling and negative control of proliferation by T-bet. In line, we showed that T-bet represses cell cycling and is associated with longer overall survival of patients with CLL. Our study uncovered a novel tumor suppressive role of T-bet in malignant B cells via its regulation of inflammatory processes and cell cycling, which has implications for the stratification and therapy of patients with CLL. Linking T-bet activity to inflammation explains the good prognostic role of genetic alterations in the inflammatory signaling pathways in CLL. |
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| DOI: | doi:10.1182/blood.2023021990 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1182/blood.2023021990 |
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| | DOI: https://doi.org/10.1182/blood.2023021990 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1930142196 |
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| Verknüpfungen: | → Zeitschrift |
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T-bet suppresses proliferation of malignant B cells in chronic lymphocytic leukemia / Rößner, Philipp M. [VerfasserIn]; August 1 2024 (Online-Ressource)
