Status: Bibliographieeintrag
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| Verfasst von: | Pollali, Evangelia [VerfasserIn]  |
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| | Draguhn, Andreas [VerfasserIn] |
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| Titel: | Differential suppression of hippocampal network oscillations by neuropeptide Y |
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| Verf.angabe: | Evangelia Pollali, Andreas Draguhn |
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| E-Jahr: | 2024 |
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| Jahr: | 24 December 2024 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 10.07.2025 |
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| Titel Quelle: | Enthalten in: Neuropharmacology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1970 |
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| Jahr Quelle: | 2025 |
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| Band/Heft Quelle: | 266(2025), Artikel-ID 110281, Seite 110281-1-110281-15 |
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| ISSN Quelle: | 1873-7064 |
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| Abstract: | Neuropeptide Y (NPY) is the most abundant neuropeptide in the brain. It exerts anxiolytic and anticonvulsive actions, reduces stress and suppresses fear memory. While its effects at the behavioral and cellular levels have been well studied, much less is known about the modulation of physiological activity patterns at the network level. We therefore studied the impact of NPY on two prominent, memory-related hippocampal activity patterns, gamma oscillations and sharp wave-ripple complexes in C57BL/6 male mice. Using established in vitro brain slice models for both patterns, we assessed the effects of NPY and receptor-specific agonists and antagonists on network activity in the CA3 and CA1 subnetworks. We report that NPY strongly suppresses sharp waves, and has significant, but much weaker effects on the power of carbachol-induced gamma oscillations. Both effects are primarily mediated via Y2 receptors. Additionally, NPY effects are much more prominent in the CA1 region compared to CA3. Our results show pattern- and region-specific effects of NPY on hippocampal networks, which suggest specific modulatory actions on hippocampus-dependent memory processes. |
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| DOI: | doi:10.1016/j.neuropharm.2024.110281 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.neuropharm.2024.110281 |
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| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S0028390824004507 |
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| | DOI: https://doi.org/10.1016/j.neuropharm.2024.110281 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Gamma oscillations |
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| | Hippocampus |
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| | Memory |
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| | Neuropeptide Y |
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| | NPY |
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| | SPW-R |
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| | Y receptors |
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| K10plus-PPN: | 1930241453 |
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| Verknüpfungen: | → Zeitschrift |
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Differential suppression of hippocampal network oscillations by neuropeptide Y / Pollali, Evangelia [VerfasserIn]; 24 December 2024 (Online-Ressource)
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