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| Verfasst von: | Kim, Yong Ryoul [VerfasserIn]  |
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| | Joo, Jaegeon [VerfasserIn] |
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| | Lee, Hee Jung [VerfasserIn] |
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| | Kim, Chaelim [VerfasserIn] |
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| | Park, Ju-Chan [VerfasserIn] |
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| | Yu, Young Suk [VerfasserIn] |
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| | Kim, Chang Rok [VerfasserIn] |
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| | Lee, Do Hui [VerfasserIn] |
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| | Cha, Joowon [VerfasserIn] |
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| | Kwon, Hyemin [VerfasserIn] |
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| | Hanssen, Kimberley M. [VerfasserIn] |
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| | Grünewald, Thomas G. P. [VerfasserIn] |
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| | Choi, Murim [VerfasserIn] |
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| | Han, Ilkyu [VerfasserIn] |
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| | Bae, Sangsu [VerfasserIn] |
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| | Jung, Inkyung [VerfasserIn] |
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| | Shin, Yongdae [VerfasserIn] |
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| | Baek, Sung Hee [VerfasserIn] |
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| Titel: | Prion-like domain mediated phase separation of ARID1A promotes oncogenic potential of Ewing’s sarcoma |
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| Verf.angabe: | Yong Ryoul Kim, Jaegeon Joo, Hee Jung Lee, Chaelim Kim, Ju-Chan Park, Young Suk Yu, Chang Rok Kim, Do Hui Lee, Joowon Cha, Hyemin Kwon, Kimberley M. Hanssen, Thomas G.P. Grünewald, Murim Choi, Ilkyu Han, Sangsu Bae, Inkyung Jung, Yongdae Shin & Sung Hee Baek |
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| E-Jahr: | 2024 |
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| Jahr: | 03 August 2024 |
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| Umfang: | 18 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 14.07.2025 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 15(2024), Artikel-ID 6569, Seite 1-18 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Liquid-liquid phase separation (LLPS) facilitates the formation of membraneless organelles within cells, with implications in various biological processes and disease states. AT-rich interactive domain-containing protein 1A (ARID1A) is a chromatin remodeling factor frequently associated with cancer mutations, yet its functional mechanism remains largely unknown. Here, we find that ARID1A harbors a prion-like domain (PrLD), which facilitates the formation of liquid condensates through PrLD-mediated LLPS. The nuclear condensates formed by ARID1A LLPS are significantly elevated in Ewing’s sarcoma patient specimen. Disruption of ARID1A LLPS results in diminished proliferative and invasive abilities in Ewing’s sarcoma cells. Through genome-wide chromatin structure and transcription profiling, we identify that the ARID1A condensate localizes to EWS/FLI1 target enhancers and induces long-range chromatin architectural changes by forming functional chromatin remodeling hubs at oncogenic target genes. Collectively, our findings demonstrate that ARID1A promotes oncogenic potential through PrLD-mediated LLPS, offering a potential therapeutic approach for treating Ewing’s sarcoma. |
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| DOI: | doi:10.1038/s41467-024-51050-0 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41467-024-51050-0 |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41467-024-51050-0 |
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| | DOI: https://doi.org/10.1038/s41467-024-51050-0 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cell biology |
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| | Chromatin remodelling |
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| | Epigenomics |
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| K10plus-PPN: | 1930405057 |
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| Verknüpfungen: | → Zeitschrift |
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Prion-like domain mediated phase separation of ARID1A promotes oncogenic potential of Ewing’s sarcoma / Kim, Yong Ryoul [VerfasserIn]; 03 August 2024 (Online-Ressource)
