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Verfasst von:Griffiths, Gillian [VerfasserIn]   i
 Brügger, Britta [VerfasserIn]   i
 Freund, Christian [VerfasserIn]   i
Titel:Lipid switches in the immunological synapse
Verf.angabe:Gillian Griffiths, Britta Brügger, and Christian Freund
E-Jahr:2024
Jahr:July 2024
Umfang:13 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 10.07.2025
Titel Quelle:Enthalten in: The journal of biological chemistry
Ort Quelle:Bethesda, Md. : ASBMB Publications, 1905
Jahr Quelle:2024
Band/Heft Quelle:300(2024), 7 vom: Juli, Artikel-ID 107428, Seite 1-13
ISSN Quelle:1083-351X
Abstract:Adaptive immune responses comprise the activation of T cells by peptide antigens that are presented by proteins of the Major Histocompatibility Complex (MHC) on the surface of an antigen-presenting cell. As a consequence of the T cell receptor interacting productively with a certain peptide-MHC complex, a specialized cell-cell junction known as the immunological synapse forms and is accompanied by changes in the spatiotemporal patterning and function of intracellular signaling molecules. Key modifications occurring at the cytoplasmic leaflet of the plasma and internal membranes in activated T cells comprise lipid switches that affect the binding and distribution of proteins within or near the lipid bilayer. Here, we describe two major classes of lipid switches that act at this critical water/membrane interface. Phosphoinositides are derived from phosphatidylinositol, an amphiphilic molecule that contains two fatty acid chains and a phosphate group that bridges the glycerol backbone to the carbohydrate inositol. The inositol ring can be variably (de-)phosphorylated by dedicated kinases and phosphatases, thereby creating phosphoinositide signatures that define the composition and properties of signaling molecules, molecular complexes, or whole organelles. Palmitoylation refers to the reversible attachment of the fatty acid palmitate to a substrate protein’s cysteine residue. DHHC enzymes, named after the four conserved amino acids in their active site, catalyze this post-translational modification and thereby change the distribution of proteins at, between, and within membranes. T cells utilize these two types of molecular switches to adjust their properties to an activation process that requires changes in motility, transport, secretion, and gene expression.
DOI:doi:10.1016/j.jbc.2024.107428
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1016/j.jbc.2024.107428
 kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S002192582401929X
 DOI: https://doi.org/10.1016/j.jbc.2024.107428
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:DHHC enzymes
 immunological synapse
 palmitoylation
 phosphoinositides
 S-acylation
 T cell
K10plus-PPN:1930501668
Verknüpfungen:→ Zeitschrift

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