| |  Online-Ressource |
|---|
| Verfasst von: | Szabó, Gábor [VerfasserIn]  |
|---|
| | Bährle-Szabó, Susanne [VerfasserIn] |
|---|
| | Bátkai, Sándor [VerfasserIn] |
|---|
| | Stumpf, Nicole [VerfasserIn] |
|---|
| | Dengler, Thomas [VerfasserIn] |
|---|
| | Zimmermann, Rainer Johannes [VerfasserIn] |
|---|
| | Vahl, Christian-Friedrich [VerfasserIn] |
|---|
| | Hagl, Siegfried [VerfasserIn] |
|---|
| Titel: | l-arginine |
|---|
| Titelzusatz: | effect on reperfusion injury after heart transplantation |
|---|
| Verf.angabe: | Gábor Szabó, Susanne Bährle, Sándor Bátkai, Nicole Stumpf, Thomas J. Dengler, Rainer Zimmermann, Christian F. Vahl, Siegfried Hagl |
|---|
| E-Jahr: | 1998 |
|---|
| Jahr: | 01 August 1998 |
|---|
| Umfang: | 8 S. |
|---|
| Fussnoten: | Gesehen am 15.07.2025 |
|---|
| Titel Quelle: | Enthalten in: World journal of surgery |
|---|
| Ort Quelle: | [Hoboken, New Jersey : Wiley, 1977 |
|---|
| Jahr Quelle: | 1998 |
|---|
| Band/Heft Quelle: | 22(1998), 8, Seite 791-798 |
|---|
| ISSN Quelle: | 1432-2323 |
|---|
| Abstract: | Global myocardial ischemia and reperfusion injury play a major role in early postoperative myocardial graft dysfunction. The aim of the present study was to investigate the effects of the nitric oxide (NO) precursor l-arginine on myocardial and endothelial function after hypothermic ischemia and reperfusion in a heterotopic rat heart transplantation model. After 1 hour ischemic preservation, reperfusion was started after application of placebo (control, n= 12) or l-arginine (l-Arg 40 mg/kg, n= 12), a substrate of NO synthesis. Myocardial blood flow (MBF) was assessed by the hydrogen clearance method. An implanted balloon was used to obtain pressure-volume relations of the transplanted heart. Left ventricular developed pressure (LVDP), rate of pressure development (dP/dt), end-diastolic pressure (LVEDP), isovolumic relaxation constant (TE), and MBF were measured after 60 minutes and 24 hours of reperfusion. Endothelium-dependent vasodilatation in response to acetylcholine (ACh) and endothelium-independent vasodilatation in response to sodium nitroprusside (SNP) were also determined. After 1 hour the MBF was significantly higher in the l-Arg group (3.6 ± 0.6 vs. 1.9 ± 0.2 ml/min/g, p < 0.05). The l-Arg group showed better recovery of systolic function and myocardial relaxation (LVDP 106 ± 6 vs. 70 ± 7 mmHg, p < 0.05; maximal dP/dt 5145 ± 498 vs. 3410 ± 257 mmHg/s, p < 0.05; TE 12.1 ± 0.9 vs. 16.1 ± 1.5 ms, p < 0.05, at an intraventricular volume of 80 μl). LVEDP was similar in the two groups. After 24 hours no difference was found between the groups for basal MBF, LVP, dP/dt, TE, LVEDP, or the response of MBF to SNP. However, ACh led to a significantly higher increase in MBF in the l-Arg group (52 ± 8% vs. 29 ± 7%,p < 0.05). These results indicate that (1) NO donation improves myocardial and endothelial functional recovery during early reperfusion after heart transplantation; and (2) initial treatment with l-Arg has a persisting beneficial effect against reperfusion-induced graft coronary endothelial dysfunction during late reperfusion. |
|---|
| DOI: | doi:10.1007/s002689900471 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s002689900471 |
|---|
| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1007/s002689900471 |
|---|
| | DOI: https://doi.org/10.1007/s002689900471 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Coronary Endothelial Dysfunction |
|---|
| | Heart Transplantation Model |
|---|
| | Left Ventricular Develop Pressure |
|---|
| | Myocardial Blood Flow |
|---|
| | Nitric Oxide |
|---|
| K10plus-PPN: | 1930538030 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
