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| Verfasst von: | Salg, Gabriel Alexander [VerfasserIn]  |
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| | Steinle, Verena [VerfasserIn] |
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| | Labode, Jonas [VerfasserIn] |
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| | Wagner, Willi Linus [VerfasserIn] |
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| | Studier-Fischer, Alexander [VerfasserIn] |
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| | Reiser, Johanna [VerfasserIn] |
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| | Farjallah, Elyes [VerfasserIn] |
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| | Güttlein, Michelle [VerfasserIn] |
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| | Albers, Jonas [VerfasserIn] |
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| | Hilgenfeld, Tim [VerfasserIn] |
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| | Giese, Nathalia [VerfasserIn] |
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| | Stiller, Wolfram [VerfasserIn] |
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| | Nickel, Felix [VerfasserIn] |
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| | Loos, Martin [VerfasserIn] |
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| | Michalski, Christoph [VerfasserIn] |
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| | Kauczor, Hans-Ulrich [VerfasserIn] |
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| | Hackert, Thilo [VerfasserIn] |
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| | Dullin, Christian [VerfasserIn] |
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| | Mayer, Philipp [VerfasserIn] |
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| | Kenngott, Hannes Götz [VerfasserIn] |
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| Titel: | Multiscale and multimodal imaging for three-dimensional vascular and histomorphological organ structure analysis of the pancreas |
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| Verf.angabe: | Gabriel Alexander Salg, Verena Steinle, Jonas Labode, Willi Wagner, Alexander Studier-Fischer, Johanna Reiser, Elyes Farjallah, Michelle Guettlein, Jonas Albers, Tim Hilgenfeld, Nathalia A. Giese, Wolfram Stiller, Felix Nickel, Martin Loos, Christoph W. Michalski, Hans-Ulrich Kauczor, Thilo Hackert, Christian Dullin, Philipp Mayer & Hannes Goetz Kenngott |
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| E-Jahr: | 2024 |
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| Jahr: | 02 May 2024 |
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| Umfang: | 15 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 16.07.2025 |
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| Titel Quelle: | Enthalten in: Scientific reports |
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| Ort Quelle: | [London] : Springer Nature, 2011 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 14(2024), Artikel-ID 10136, Seite 1-15 |
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| ISSN Quelle: | 2045-2322 |
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| Abstract: | Exocrine and endocrine pancreas are interconnected anatomically and functionally, with vasculature facilitating bidirectional communication. Our understanding of this network remains limited, largely due to two-dimensional histology and missing combination with three-dimensional imaging. In this study, a multiscale 3D-imaging process was used to analyze a porcine pancreas. Clinical computed tomography, digital volume tomography, micro-computed tomography and Synchrotron-based propagation-based imaging were applied consecutively. Fields of view correlated inversely with attainable resolution from a whole organism level down to capillary structures with a voxel edge length of 2.0 µm. Segmented vascular networks from 3D-imaging data were correlated with tissue sections stained by immunohistochemistry and revealed highly vascularized regions to be intra-islet capillaries of islets of Langerhans. Generated 3D-datasets allowed for three-dimensional qualitative and quantitative organ and vessel structure analysis. Beyond this study, the method shows potential for application across a wide range of patho-morphology analyses and might possibly provide microstructural blueprints for biotissue engineering. |
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| DOI: | doi:10.1038/s41598-024-60254-9 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41598-024-60254-9 |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41598-024-60254-9 |
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| | DOI: https://doi.org/10.1038/s41598-024-60254-9 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Imaging |
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| | Pancreas |
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| | X-ray tomography |
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| K10plus-PPN: | 1930685459 |
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| Verknüpfungen: | → Zeitschrift |
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Multiscale and multimodal imaging for three-dimensional vascular and histomorphological organ structure analysis of the pancreas / Salg, Gabriel Alexander [VerfasserIn]; 02 May 2024 (Online-Ressource)
