| Online-Ressource |
Verfasst von: | Salg, Gabriel Alexander [VerfasserIn]  |
| Steinle, Verena [VerfasserIn]  |
| Labode, Jonas [VerfasserIn]  |
| Wagner, Willi Linus [VerfasserIn]  |
| Studier-Fischer, Alexander [VerfasserIn]  |
| Reiser, Johanna [VerfasserIn]  |
| Farjallah, Elyes [VerfasserIn]  |
| Güttlein, Michelle [VerfasserIn]  |
| Albers, Jonas [VerfasserIn]  |
| Hilgenfeld, Tim [VerfasserIn]  |
| Giese, Nathalia [VerfasserIn]  |
| Stiller, Wolfram [VerfasserIn]  |
| Nickel, Felix [VerfasserIn]  |
| Loos, Martin [VerfasserIn]  |
| Michalski, Christoph [VerfasserIn]  |
| Kauczor, Hans-Ulrich [VerfasserIn]  |
| Hackert, Thilo [VerfasserIn]  |
| Dullin, Christian [VerfasserIn]  |
| Mayer, Philipp [VerfasserIn]  |
| Kenngott, Hannes Götz [VerfasserIn]  |
Titel: | Multiscale and multimodal imaging for three-dimensional vascular and histomorphological organ structure analysis of the pancreas |
Verf.angabe: | Gabriel Alexander Salg, Verena Steinle, Jonas Labode, Willi Wagner, Alexander Studier-Fischer, Johanna Reiser, Elyes Farjallah, Michelle Guettlein, Jonas Albers, Tim Hilgenfeld, Nathalia A. Giese, Wolfram Stiller, Felix Nickel, Martin Loos, Christoph W. Michalski, Hans-Ulrich Kauczor, Thilo Hackert, Christian Dullin, Philipp Mayer & Hannes Goetz Kenngott |
E-Jahr: | 2024 |
Jahr: | 02 May 2024 |
Umfang: | 15 S. |
Illustrationen: | Illustrationen |
Fussnoten: | Gesehen am 16.07.2025 |
Titel Quelle: | Enthalten in: Scientific reports |
Ort Quelle: | [London] : Springer Nature, 2011 |
Jahr Quelle: | 2024 |
Band/Heft Quelle: | 14(2024), Artikel-ID 10136, Seite 1-15 |
ISSN Quelle: | 2045-2322 |
Abstract: | Exocrine and endocrine pancreas are interconnected anatomically and functionally, with vasculature facilitating bidirectional communication. Our understanding of this network remains limited, largely due to two-dimensional histology and missing combination with three-dimensional imaging. In this study, a multiscale 3D-imaging process was used to analyze a porcine pancreas. Clinical computed tomography, digital volume tomography, micro-computed tomography and Synchrotron-based propagation-based imaging were applied consecutively. Fields of view correlated inversely with attainable resolution from a whole organism level down to capillary structures with a voxel edge length of 2.0 µm. Segmented vascular networks from 3D-imaging data were correlated with tissue sections stained by immunohistochemistry and revealed highly vascularized regions to be intra-islet capillaries of islets of Langerhans. Generated 3D-datasets allowed for three-dimensional qualitative and quantitative organ and vessel structure analysis. Beyond this study, the method shows potential for application across a wide range of patho-morphology analyses and might possibly provide microstructural blueprints for biotissue engineering. |
DOI: | doi:10.1038/s41598-024-60254-9 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41598-024-60254-9 |
| kostenfrei: Volltext: https://www.nature.com/articles/s41598-024-60254-9 |
| DOI: https://doi.org/10.1038/s41598-024-60254-9 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Imaging |
| Pancreas |
| X-ray tomography |
K10plus-PPN: | 1930685459 |
Verknüpfungen: | → Zeitschrift |
Multiscale and multimodal imaging for three-dimensional vascular and histomorphological organ structure analysis of the pancreas / Salg, Gabriel Alexander [VerfasserIn]; 02 May 2024 (Online-Ressource)