T cell awareness of paternal alloantigens during pregnancy

• Verfasst von: Tafuri, Anna [VerfasserIn]
• Verfasst von: Alferink, Judith [VerfasserIn]
• Verfasst von: Möller, Peter [VerfasserIn]
• Verfasst von: Hämmerling, Günter J. [VerfasserIn]
• Verfasst von: Arnold, Bernd [VerfasserIn]
• Titel: T cell awareness of paternal alloantigens during pregnancy
• Verf.angabe: Anna Tafuri, Judith Alferink, Peter Möller, Günter J. Hämmerling, Bernd Arnold
• E-Jahr: 1995
• Jahr: October 27, 1995
• Umfang: 4 S.
• Fussnoten: Gesehen am 17.07.2025
• Titel Quelle: Enthalten in: Science
• Ort Quelle: Washington, DC : American Association for the Advancement of Science, 1880
• Jahr Quelle: 1995
• Band/Heft Quelle: 270(1995), 5236, Seite 630-633
• ISSN Quelle: 1095-9203
• DOI: doi:10.1126/science.270.5236.630
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1931017077

Abstract

During pregnancy a semiallogeneic fetus survives despite the presence of maternal T cells specific for paternally inherited histocompatibility antigens. A mouse transgenic for a T cell receptor recognizing the major histocompatibility (MHC) antigen H-2Kb was used to follow the fate of T cells reactive to paternal alloantigens. In contrast to syngeneic and third-party allogeneic pregnancies, mice bearing a Kb-positive conceptus had reduced numbers of Kb-reactive T cells and accepted Kb-positive tumor grafts. T cell phenotype and responsiveness were restored after delivery. Thus, during pregnancy maternal T cells acquire a transient state of tolerance specific for paternal alloantigens.