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| Verfasst von: | Stich, Maximilian [VerfasserIn]  |
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| | Magalhães, Vladimir Gonçalves [VerfasserIn] |
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| | Bürger, Friederike [VerfasserIn] |
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| | Garbade, Sven [VerfasserIn] |
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| | Jeltsch, Kathrin [VerfasserIn] |
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| | Mohr, Kerstin [VerfasserIn] |
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| | Haddad, Anneke [VerfasserIn] |
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| | Elling, Roland [VerfasserIn] |
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| | Lang, Peter [VerfasserIn] |
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| | Rabsteyn, Armin [VerfasserIn] |
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| | Jacobsen, Eva-Maria [VerfasserIn] |
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| | Bode, Sebastian F. N. [VerfasserIn] |
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| | Müller, Barbara [VerfasserIn] |
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| | Kräusslich, Hans-Georg [VerfasserIn] |
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| | Hoffmann, Georg F. [VerfasserIn] |
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| | Okun, Jürgen G. [VerfasserIn] |
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| | Bartenschlager, Ralf [VerfasserIn] |
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| | Binder, Marco [VerfasserIn] |
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| | Janda, Aleš [VerfasserIn] |
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| | Renk, Hanna [VerfasserIn] |
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| | Tönshoff, Burkhard [VerfasserIn] |
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| Titel: | Elevated soluble ACE2 activity in children and adults after SARS-CoV-2 exposure irrespective of laboratory-confirmed infection |
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| Titelzusatz: | research article |
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| Verf.angabe: | Maximilian Stich, Vladimir Gonçalves Magalhães, Friederike Bürger, Sven F. Garbade, Kathrin Jeltsch, Kerstin Mohr, Anneke Haddad, Roland Elling, Peter Lang, Armin Rabsteyn, Eva-Maria Jacobsen, Sebastian F.N. Bode, Barbara Müller, Hans-Georg Kräusslich, Georg Friedrich Hoffmann, Jürgen G. Okun, Ralf Bartenschlager, Marco Binder, Aleš Janda, Hanna Renk, Burkhard Tönshoff |
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| E-Jahr: | 2024 |
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| Jahr: | December 2024 |
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| Umfang: | 12 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 03. Dezember 2024 ; Gesehen am 18.07.2025 |
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| Titel Quelle: | Enthalten in: Journal of medical virology |
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| Ort Quelle: | Bognor Regis [u.a.] : Wiley, 1977 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 96(2024), 12 vom: Dez., Artikel-ID e70098, Seite 1-12 |
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| ISSN Quelle: | 1096-9071 |
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| Abstract: | The pivotal role of the cell entry receptor ACE2 for SARS-CoV-2 infection is well-established. When ACE2 is shed from cell surface into plasma as soluble ACE2 (sACE2), it can effectively neutralize SARS-CoV-2. This longitudinal prospective cohort study analyzed sACE2 activity in 1192 participants, aged 4 months to 81 years, 3 and 12 months after SARS-CoV-2 household exposure. Following SARS-CoV-2 exposure, participants exhibited significantly elevated sACE2 activity, irrespective of confirmed infection, with the highest levels observed in exposed children. Longitudinal analysis revealed a decline in sACE2 levels over time, reaching levels comparable to age- and sex-matched pre-pandemic controls. An increase in sACE2 activity was also confirmed in vitro in Calu-3 (human lung) cells within hours of SARS-CoV-2 exposure, providing a direct link between SARS-CoV-2 exposure and elevated sACE2. This study, therefore, challenges the dichotomy of categorizing SARS-CoV-2 exposed participants as infected or not infected solely on currently established diagnostic assays. It demonstrates lasting host responses independent of B- and T-cell memory and may help to keep SARS-CoV-2 infections in balance and contribute to successful virus clearance in children and adults lacking humoral and cellular immune responses following SARS-CoV-2 exposure. Trial Registration: German Registry for Clinical Studies; Identifier: D 00021521. |
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| DOI: | doi:10.1002/jmv.70098 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1002/jmv.70098 |
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| | kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.70098 |
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| | DOI: https://doi.org/10.1002/jmv.70098 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | ACE2 |
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| | children |
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| | exposure |
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| | persistence |
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| | SARS-CoV-2 |
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| K10plus-PPN: | 1931292345 |
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| Verknüpfungen: | → Zeitschrift |
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Elevated soluble ACE2 activity in children and adults after SARS-CoV-2 exposure irrespective of laboratory-confirmed infection / Stich, Maximilian [VerfasserIn]; December 2024 (Online-Ressource)
