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| Verfasst von: | Simon, Malte [VerfasserIn]  |
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| | Stüve, Philipp [VerfasserIn] |
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| | Schmidleithner, Lisa [VerfasserIn] |
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| | Bittner, Sebastian [VerfasserIn] |
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| | Beumer, Niklas [VerfasserIn] |
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| | Strieder, Nicholas [VerfasserIn] |
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| | Schmidl, Christian [VerfasserIn] |
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| | Pant, Asmita [VerfasserIn] |
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| | Gebhard, Claudia [VerfasserIn] |
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| | Eigenberger, Andreas [VerfasserIn] |
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| | Rehli, Michael [VerfasserIn] |
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| | Prantl, Lukas [VerfasserIn] |
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| | Hehlgans, Thomas [VerfasserIn] |
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| | Brors, Benedikt [VerfasserIn] |
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| | Imbusch, Charles [VerfasserIn] |
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| | Delacher, Michael [VerfasserIn] |
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| | Feuerer, Markus [VerfasserIn] |
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| Titel: | Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells |
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| Verf.angabe: | Malte Simon, Philipp Stüve, Lisa Schmidleithner, Sebastian Bittner, Niklas Beumer, Nicholas Strieder, Christian Schmidl, Asmita Pant, Claudia Gebhard, Andreas Eigenberger, Michael Rehli, Lukas Prantl, Thomas Hehlgans, Benedikt Brors, Charles D. Imbusch, Michael Delacher, and Markus Feuerer |
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| E-Jahr: | 2024 |
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| Jahr: | 13 August 2024 |
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| Umfang: | 30 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 23. Juli 2024, Artikelversion: 13. August 2024 ; Gesehen am 18.07.2025 |
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| Titel Quelle: | Enthalten in: Immunity |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1994 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 57(2024), 8 vom: Aug., Seite 1975-1993.e10 |
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| ISSN Quelle: | 1097-4180 |
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| Abstract: | Tissue adaptation is required for regulatory T (Treg) cell function within organs. Whether this program shares aspects with other tissue-localized immune populations is unclear. Here, we analyzed single-cell chromatin accessibility data, including the transposable element (TE) landscape of CD45+ immune cells from colon, skin, adipose tissue, and spleen. We identified features of organ-specific tissue adaptation across different immune cells. Focusing on tissue Treg cells, we found conservation of the Treg tissue adaptation program in other tissue-localized immune cells, such as amphiregulin-producing T helper (Th)17 cells. Accessible TEs can act as regulatory elements, but their contribution to tissue adaptation is not understood. TE landscape analysis revealed an enrichment of specific transcription factor binding motifs in TE regions within accessible chromatin peaks. TEs, specifically from the LTR family, were located in enhancer regions and associated with tissue adaptation. These findings broaden our understanding of immune tissue residency and provide an important step toward organ-specific immune interventions. |
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| DOI: | doi:10.1016/j.immuni.2024.06.015 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.immuni.2024.06.015 |
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| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S1074761324003212 |
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| | DOI: https://doi.org/10.1016/j.immuni.2024.06.015 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | regulatory T cells |
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| | scATAC-seq |
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| | tissue adaptation |
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| | tissue-residing immune cells |
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| | transposable element |
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| | Treg cells |
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| K10plus-PPN: | 1931294755 |
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| Verknüpfungen: | → Zeitschrift |
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Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells / Simon, Malte [VerfasserIn]; 13 August 2024 (Online-Ressource)
