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| Verfasst von: | Awenius, Marcel [VerfasserIn]  |
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| | Abeln, Helen [VerfasserIn] |
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| | Müller, Melanie [VerfasserIn] |
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| | Franke, Vanessa L. [VerfasserIn] |
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| | Rincon, Gino [VerfasserIn] |
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| | Glowa, Christin [VerfasserIn] |
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| | Schmitt, Michaela [VerfasserIn] |
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| | Bangert, Renate [VerfasserIn] |
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| | Ludwig, Dominik [VerfasserIn] |
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| | Schmidt, Andreas B. [VerfasserIn] |
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| | Kuder, Tristan Anselm [VerfasserIn] |
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| | Ladd, Mark E. [VerfasserIn] |
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| | Bachert, Peter [VerfasserIn] |
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| | Biegger, Philipp [VerfasserIn] |
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| | Korzowski, Andreas [VerfasserIn] |
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| Titel: | Three-dimensional radial echo-planar spectroscopic imaging for hyperpolarized 13C MRSI in vivo |
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| Verf.angabe: | Marcel Awenius, Helen Abeln, Melanie Müller, Vanessa L. Franke, Gino Rincon, Christin Glowa, Michaela Schmitt, Renate Bangert, Dominik Ludwig, Andreas B. Schmidt, Tristan A. Kuder, Mark E. Ladd, Peter Bachert, Philipp Biegger, Andreas Korzowski |
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| E-Jahr: | 2025 |
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| Jahr: | January 2025 |
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| Umfang: | 11 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Zuerst veröffentlicht: 20. August 2024 ; Gesehen am 18.07.2025 ; Im Titel ist die Zahl "13" hochgestellt |
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| Titel Quelle: | Enthalten in: Magnetic resonance in medicine |
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| Ort Quelle: | New York, NY [u.a.] : Wiley-Liss, 1984 |
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| Jahr Quelle: | 2025 |
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| Band/Heft Quelle: | 93(2025), 1 vom: Jan., Seite 31-41 |
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| ISSN Quelle: | 1522-2594 |
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| Abstract: | Purpose To demonstrate the feasibility of 3D echo-planar spectroscopic imaging (EPSI) technique with rapid volumetric radial k-space sampling for hyperpolarized (HP) 13C magnetic resonance spectroscopic imaging (MRSI) in vivo. Methods A radial EPSI (rEPSI) was implemented on a 3 T clinical PET/MR system. To enable volumetric coverage, the sinusoidal shaped readout gradients per k-t-spoke were rotated along the three spatial dimensions in a golden-angle like manner. A distance-weighted, density-compensated gridding reconstruction was used, also in cases with undersampling of spokes in k-space. Measurements without and with HP 13C-labeled substances were performed in phantoms and rats using a double-resonant 13C/1H volume resonator with 72 mm inner diameter. Results Phantom measurements demonstrated the feasibility of the implemented rEPSI sequence, as well as the robustness to undersampling in k-space up to a factor of 5 without advanced reconstruction techniques. Applied to measurements with HP [1-13C]pyruvate in a tumor-bearing rat, we obtained well-resolved MRSI datasets with a large matrix size of 123 voxels covering the whole imaging FOV of (180 mm)3 within 6.3 s, enabling to observe metabolism in dynamic acquisitions. Conclusion After further optimization, the proposed rEPSI method may be useful in applications of HP 13C-tracers where unknown or varying metabolite resonances are expected, and the acquisition of dynamic, volumetric MRSI datasets with an adequate temporal resolution is a challenge. |
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| DOI: | doi:10.1002/mrm.30258 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1002/mrm.30258 |
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| | kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/mrm.30258 |
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| | DOI: https://doi.org/10.1002/mrm.30258 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | 13C MRSI |
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| | dynamic nuclear polarization |
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| | echo-planar |
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| | hyperpolarization |
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| | radial |
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| K10plus-PPN: | 1931299994 |
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| Verknüpfungen: | → Zeitschrift |
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Three-dimensional radial echo-planar spectroscopic imaging for hyperpolarized 13C MRSI in vivo / Awenius, Marcel [VerfasserIn]; January 2025 (Online-Ressource)
