Verfasst von: | Haneder, Stefan [VerfasserIn] |
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Giordano, Frank Anton [VerfasserIn] | |
Brehmer, Stefanie [VerfasserIn] | |
Büsing, Karen-Anett [VerfasserIn] | |
Schmiedek, Peter [VerfasserIn] | |
Schad, Lothar R. [VerfasserIn] | |
Wenz, Frederik [VerfasserIn] | |
Schönberg, Stefan [VerfasserIn] | |
Meyer, Melissa [VerfasserIn] | |
Titel: | 23Na-MRI of recurrent glioblastoma multiforme after intraoperative radiotherapy |
Titelzusatz: | technical note |
Verf.angabe: | Stefan Haneder, Frank A. Giordano, Simon Konstandin, Stefanie Brehmer, Karen A. Buesing, Peter Schmiedek, Lothar R. Schad, Frederik Wenz, Stefan O. Schoenberg, Melissa M. Ong |
Jahr des Originals: | 2014 |
Umfang: | 6 S. |
Fussnoten: | Gesehen am 02.11.2017 ; Im Titel ist „23” hochgestellt. |
Titel Quelle: | Enthalten in: Neuroradiology |
Jahr Quelle: | 2015 |
Band/Heft Quelle: | 57(2015), 3, S. 321-326 |
ISSN Quelle: | 1432-1920 |
Abstract: | Introduction: We report the first case of an intraoperative radiotherapy (IORT) in a patient with recurrent glioblastoma multiforme (GBM) who was followed up with a novel magnetic resonance imaging (MRI) method - 23Na-MRI - in comparison to a standard contrast-enhanced 1H-MRI and 18F-FET-PET. Methods: A 56-year-old female patient with diagnosed GBM in July 2012 underwent tumor resection, radiochemotherapy, and three cycles of chemotherapy. After a relapse, 6 months after the initial diagnosis, an IORT was recommended which was performed in March 2013 using the INTRABEAM system (Carl Zeiss Meditec AG, Germany) with a 3-cm applicator and a surface dose of 20 Gy. Early post-operative contrast-enhanced and 1-month follow-up 1H-MRI and a 18F-FET-PET were performed. In addition, an IRB-approved 23Na-MRI was performed on a 3.0-T MR scanner (MAGNETOM TimTrio, Siemens Healthcare, Germany). Results: After re-surgery and IORT in March 2013, only a faint contrast enhancement but considerable surrounding edema was visible at the medio-posterior resection margins. In April 2013, new and progressive contrast enhancement, edema, 23Na content, and increased uptake in the 18F-FET-PET were visible, indicating tumor recurrence. Increased sodium content within the area of contrast enhancement was found in the 23Na-MRI, but also exceeding this area, very similar to the increased uptake depicted in the 18F-FET-PET. The clearly delineable zone of edema in both examinations exhibits a lower 23Na content compared to areas with suspected proliferating tumor tissue. Conclusion: 23Na-MRI provided similar information in the suspicious area compared to 18F-FET-PET, exceeding conventional 1H-MRI. Still, 23Na-MRI remains an investigational technique, which is worth to be further evaluated. |
DOI: | doi:10.1007/s00234-014-1468-2 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt. Verlag: http://dx.doi.org/10.1007/s00234-014-1468-2 |
Verlag: https://link-springer-com.ezproxy.medma.uni-heidelberg.de/article/10.1007/s00234-014-1468-2 | |
DOI: https://doi.org/10.1007/s00234-014-1468-2 | |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1564925021 |
Verknüpfungen: | → Zeitschrift |