Verfasst von: | Deuschle, Michael [VerfasserIn] |
---|---|
Schredl, Michael [VerfasserIn] | |
Wisch, Christian [VerfasserIn] | |
Schilling, Claudia [VerfasserIn] | |
Gilles, Maria [VerfasserIn] | |
Titel: | Serum brain-derived neurotrophic factor (BDNF) in sleep-disordered patients |
Titelzusatz: | relation to sleep stage N3 and rapid eye movement (REM) sleep across diagnostic entities |
Verf.angabe: | Michael Deuschle, Michael Schredl, Christian Wisch, Claudia Schilling, Maria Gilles, Olga Geisel, Rainer Hellweg |
E-Jahr: | 2018 |
Jahr: | February 2018 |
Jahr des Originals: | 2017 |
Umfang: | 5 S. |
Teil: | volume:27 |
year:2018 | |
number:1 | |
pages:73-77 | |
extent:5 | |
Fussnoten: | First published: 28 June 2017 ; Gesehen am 22.10.2018 |
Titel Quelle: | Enthalten in: Journal of sleep research |
Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 1992 |
Jahr Quelle: | 2018 |
Band/Heft Quelle: | 27(2018), 1, Seite 73-77 |
ISSN Quelle: | 1365-2869 |
Abstract: | Experimental and clinical evidence suggests an association between neuroplasticity, brain-derived neurotrophic factor and sleep. We aimed at testing the hypotheses that brain-derived neurotrophic factor is associated with specific aspects of sleep architecture or sleep stages in patients with sleep disorders. We included 35 patients with primary insomnia, 31 patients with restless legs syndrome, 17 patients with idiopathic hypersomnia, 10 patients with narcolepsy and 37 healthy controls. Morning serum brain-derived neurotrophic factor concentrations were measured in patients and controls. In patients, blood sampling was followed by polysomnographic sleep investigation. Low brain-derived neurotrophic factor levels were associated with a low percentage of sleep stage N3 and rapid eye movement sleep across diagnostic entities. However, there was no difference in brain-derived neurotrophic factor levels between diagnostic groups. Our data indicate that serum levels of brain-derived neurotrophic factor, independent of a specific sleep disorder, are related to the proportion of sleep stage N3 and REM sleep. This preliminary observation is in accordance with the assumption that sleep stage N3 is involved in the regulation of neuroplasticity. |
DOI: | doi:10.1111/jsr.12577 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt. Volltext ; Verlag: http://dx.doi.org/10.1111/jsr.12577 |
Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/jsr.12577 | |
DOI: https://doi.org/10.1111/jsr.12577 | |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | neuroplasticity |
neurotrophic factors | |
synaptic homeostasis theory | |
K10plus-PPN: | 1582164096 |
Verknüpfungen: | → Zeitschrift |