Covering a broad dynamic range

• Verfasst von: Becker, Verena [VerfasserIn]
• Verfasst von: Schilling, Marcel [VerfasserIn]
• Verfasst von: Bachmann, Julie [VerfasserIn]
• Verfasst von: Baumann, Ute [VerfasserIn]
• Verfasst von: Raue, Andreas [VerfasserIn]
• Verfasst von: Maiwald, Thomas [VerfasserIn]
• Verfasst von: Timmer, Jens [VerfasserIn]
• Verfasst von: Klingmüller, Ursula [VerfasserIn]
• Titel: Covering a broad dynamic range
• Titelzusatz: information processing at the erythropoietin receptor
• Verf.angabe: Verena Becker, Marcel Schilling, Julie Bachmann, Ute Baumann, Andreas Raue, Thomas Maiwald, Jens Timmer, Ursula Klingmüller
• E-Jahr: 2010
• Jahr: 20 May 2010
• Umfang: 5 S.
• Fussnoten: Gesehen am 21.12.2022
• Titel Quelle: Enthalten in: Science / First release
• Ort Quelle: Washington, DC : American Association for the Advancement of Science, 2001
• Jahr Quelle: 2010
• Band/Heft Quelle: 328(2010), 5984, Seite 1404-1408
• DOI: doi:10.1126/science.1184913
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1828250716

Abstract

Cell surface receptors convert extracellular cues into receptor activation, thereby triggering intracellular signaling networks and controlling cellular decisions. A major unresolved issue is the identification of receptor properties that critically determine processing of ligand-encoded information. We show by mathematical modeling of quantitative data and experimental validation that rapid ligand depletion and replenishment of the cell surface receptor are characteristic features of the erythropoietin (Epo) receptor (EpoR). The amount of Epo-EpoR complexes and EpoR activation integrated over time corresponds linearly to ligand input; this process is carried out over a broad range of ligand concentrations. This relation depends solely on EpoR turnover independent of ligand binding, which suggests an essential role of large intracellular receptor pools. These receptor properties enable the system to cope with basal and acute demand in the hematopoietic system.