Cooley's Anemia

• Titel: Cooley's Anemia
• Titelzusatz: ninth symposium ; [... manuscripts stemming from the "Ninth Cooley's Anemia Symposium," held October 21 - 24, 2009 at the New York Academy of Sciences ...]
• Mitwirkende: Vichinsky, Elliott P. [Hrsg.]
• Institutionen: New York Academy of Sciences
• Institutionen: Cooley's Anemia Symposium <9, 2009, New York, NY>
• Verf.angabe: issue ed. Elliott P. Vichinsky ...
• Verlagsort: Boston, Mass.
• Verlag: Blackwell
• Jahr: 2010
• Umfang: XIII, 254 S.
• Illustrationen: Ill., graph. Darst.
• Gesamttitel/Reihe: Annals of the New York Academy of Sciences ; vol. 1202 : Issue
• Fussnoten: Literaturangaben
• Inhalt: Clinical trials in thalassemia: insights from the patient community -- Pathogenesis and management of iron toxicity in thalassemia -- The role of antioxidants and iron chelators in the treatment of oxidative stress in thalassemia -- Thalassemia as a global health problem: recent progress toward its control in the developing countries -- Iron metabolism and ineffective erythropoiesis in [beta]-thalassemia mouse models -- Hepcidin in [beta]-thalassemia -- Therapy for [beta]-globinopathies: a brief review and determinants for successful and safe correction -- Humanized mouse models of Cooley's anemia: correct fetal-to-adult hemoglobin switching, disease onset, and disease pathology -- Strategy for a multicenter phase I clinical trial to evaluate globin gene transfer in [beta]-thalassemia -- Hematopoietic stem cell mobilization strategies for gene therapy of beta thalassemia and sickle cell disease -- Transcriptional silencing of fetal hemoglobin by BCL11A -- The challenge of obtaining therapeutic levels of genetically modified hematopoietic stem cells in [beta]-thalassemia patients -- Deferiprone -- Combined iron chelation therapy -- Deferasirox: current knowledge and future challenges -- Monitoring the efficiency of iron chelation therapy: the potential of nontransferrin-bound iron -- Critical appraisal of growth retardation and pubertal disturbances in thalassemia -- Magnetic resonance assessment of iron overload by separate measurement of tissue ferritin and hemosiderin iron -- Predicting pituitary iron and endocrine dysfunction -- Better survival and less cardiac morbidity in female patients with thalassemia major: a review of the literature
• Inhalt: A preclinical approach for gene therapy of [beta]-thalassemia -- The role of reduced intensity preparative regimens in patients with thalassemia given hematopoietic transplantation -- Progress in hematopoietic stem cell transplantation as allogeneic cellular gene therapy in thalassemia -- Emerging insights in the management of hemoglobin E beta thalassemia -- Fetal globin gene inducers: novel agents and new potential -- Detection of the cardiovascular complications of thalassemia by echocardiography -- Cardiovascular MRI in thalassemia major -- Complexity of alpha thalassemia: growing health problem with new approaches to screening, diagnosis, and therapy -- Nutritional deficiencies in patients with thalassemia -- Ferritin iron minerals are chelator targets, antioxidants, and coated, dietary iron -- Pulmonary hypertension in thalassemia -- The natural history of thalassemia intermedia -- Hepcidin and Hfe in iron overload in [beta]-thalassemia -- Fertility potential in thalassemia major women: current findings and future diagnostic tools -- Redefining thalassemia as a hypercoagulable state -- Treatment options for thalassemia patients with osteoporosis -- Health care transition in thalassemia: pediatric to adult-oriented care -- Ninth Cooley's Anemia Symposium: summary and perspective.
• ISBN: 1-57331-782-9
• ISBN: 978-1-57331-782-5
• Schlagwörter: (s)Anämie / (s)Thalassämie
• Dokumenttyp: Konferenzschrift: (2009 : New York, NY)
• Sprache: eng
• K10plus-PPN: 634874713

Abstract

"This volume presents manuscripts stemming from the 'Ninth Cooley's Anemia Symposium,' held October 21-24, 2009 at the New York Academy of Sciences, and sponsored by the Cooley's Anemia Foundation and the New York Academy of Sciences"--Contents p