Metastasis of prostate cancer and melanoma cells in a preclinical in vivo mouse model is enhanced by L-plastin expression and phosphorylation

• Titel: Metastasis of prostate cancer and melanoma cells in a preclinical in vivo mouse model is enhanced by L-plastin expression and phosphorylation
• Mitwirkende: Riplinger, Selina
• Mitwirkende: Wabnitz, Guido H.
• Mitwirkende: Kirchgessner, Henning
• Mitwirkende: Jahraus, Beate
• Mitwirkende: Lasitschka, Felix
• Mitwirkende: Schulte, Bianca
• Mitwirkende: Nakchbandi, Inaam
• Mitwirkende: Samstag, Yvonne
• Verf.angabe: Selina M. Riplinger, Guido H. Wabnitz, Henning Kirchgessner, Beate Jahraus, Felix Lasitschka, Bianca Schulte, Gabri van der Pluijm, Geertje van der Horst, Günter J. Hämmerling, Inaam Nakchbandi, and Yvonne Samstag
• Jahr: 2014
• Umfang: 12 S.
• Teil: volume:13
• Teil: year:2014
• Teil: pages:?
• Teil: extent:12
• Fussnoten: Gesehen am 22.08.2014
• Titel Quelle: In: Molecular cancer
• Ort Quelle: London : Biomed Central, 2002
• Jahr Quelle: 2014
• Band/Heft Quelle: 13(2014) Artikelnr. 10, 12 S.
• ISSN Quelle: 1476-4598
• DOI: doi:10.1186/1476-4598-13-10
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Actin cytoskeleton
• Sach-SW: L-plastin
• Sach-SW: Melanoma
• Sach-SW: Metastasis
• Sach-SW: Prostate cancer
• K10plus-PPN: 1482827689

Abstract

Tumor cell migration and metastasis require dynamic rearrangements of the actin cytoskeleton. Interestingly, the F-actin cross-linking and stabilizing protein L-plastin, originally described as a leukocyte specific protein, is aberrantly expressed in several non-hematopoietic malignant tumors. Therefore, it has been discussed as a tumor marker. However, systematic in vivo analyses of the functional relevance of L-plastin for tumor cell metastasis were so far lacking.