The hematopoietic cytokine granulocyte-macrophage colony stimulating factor is important for cognitive functions

• Titel: The hematopoietic cytokine granulocyte-macrophage colony stimulating factor is important for cognitive functions
• Mitwirkende: Krieger, Markus [VerfasserIn]
• Mitwirkende: Both, Martin [VerfasserIn]
• Mitwirkende: Kranig, Simon A. [VerfasserIn]
• Mitwirkende: Draguhn, Andreas [VerfasserIn]
• Verf.angabe: Markus Krieger, Martin Both, Simon A. Kranig, Claudia Pitzer, Matthias Klugmann, Gerhard Vogt, Andreas Draguhn & Armin Schneider
• E-Jahr: 2012
• Jahr: 26 September 2012
• Umfang: 10 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 18.12.2024
• Titel Quelle: Enthalten in: Scientific reports
• Ort Quelle: [London] : Springer Nature, 2011
• Jahr Quelle: 2012
• Band/Heft Quelle: 2(2012), Artikel-ID 697, Seite 1-10
• ISSN Quelle: 2045-2322
• DOI: doi:10.1038/srep00697
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Genetics of the nervous system
• Sach-SW: Molecular neuroscience
• K10plus-PPN: 1485768578

Abstract

We recently reported expression of hematopoietic growth factor GM-CSF and its receptor (GM-CSFR) in CNS neurons. Here we evaluated this system in learning and memory formation using GM-CSF deficient mice. In complementation, GM-CSF signalling was manipulated specifically in adult murine hippocampus by adeno-associated virus (AAV)-mediated GM-CSFR alpha overexpression or knock-down. GM-CSF ablation caused various hippocampus and amygdala-dependent deficits in spatial and fear memory while rendering intact basic parameters like motor function, inherent anxiety and pain threshold levels. Corroborating these data, spatial memory of AAV-injected mice was positively correlated with GM-CSFRα expression levels. Hippocampal neurons of knock-out mice showed markedly pruned dendritic trees, reduced spine densities and lower percentages of mature spines. Despite such morphological alterations, long-term potentiation (LTP) was unimpaired in the knock-out hippocampus. Collectively, these results suggest that GM-CSF signalling plays a major role in structural plasticity relevant to learning and memory.