Donor liver histology

• Verfasst von: Flechtenmacher, Christa [VerfasserIn]
• Verfasst von: Schirmacher, Peter [VerfasserIn]
• Verfasst von: Schemmer, Peter [VerfasserIn]
• Titel: Donor liver histology
• Titelzusatz: a valuable tool in graft selection
• Verf.angabe: Christa Flechtenmacher, Peter Schirmacher, Peter Schemmer
• Umfang: 7 S.
• Fussnoten: Gesehen am 04.04.2015
• Titel Quelle: Enthalten in: Langenbeck's archives of surgery
• Jahr Quelle: 2015
• Band/Heft Quelle: 400(2015), 5, S. 551-557
• ISSN Quelle: 1435-2451
• DOI: doi:10.1007/s00423-015-1298-7
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1556254660

Abstract

BackgroundDue to a tremendous organ shortage, livers from donors with extended criteria are increasingly considered for transplantation. Pathologists are more and more requested to evaluate these livers histopathologically using frozen sections at high urgency for acceptability.MethodsThis article reviews the current knowledge on pre-transplant histology in liver transplantation. Prerequisites and conditions for proper pre-transplant evaluation of donor liver tissue are discussed as well as frozen section evaluation and reporting. Data sources include the relevant medical literature, web sites specialized in organ transplantation, and the authors’ experiences in liver transplant centers.ConclusionsPre-transplant histopathological evaluation is a time-effective, accurate, and reliable tool to assess liver quality from candidate deceased donors. Pre-transplant biopsies are of value in the selection of donor livers for transplantation, especially in case of extended criteria donors, and should be performed more frequently in order to avoid unnecessary loss of organs suitable for transplantation and transplantation of inappropriate organs. Correlation of histopathological findings with clinical conditions is essential and requires excellent communication between pathologists, surgeons, and the other members of the transplant team.