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| Verfasst von: | Fricke, Fabia [VerfasserIn]  |
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| | Lee, Jennifer [VerfasserIn] |
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| | Michalak, Malwina [VerfasserIn] |
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| | Haußer-Siller, Ingrid [VerfasserIn] |
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| | Suarez-Carmona, Meggy [VerfasserIn] |
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| | Halama, Niels [VerfasserIn] |
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| | Kopitz, Jürgen [VerfasserIn] |
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| | Gebert, Johannes [VerfasserIn] |
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| Titel: | TGFBR2-dependent alterations of exosomal cargo and functions in DNA mismatch repair-deficient HCT116 colorectal cancer cells |
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| Verf.angabe: | Fabia Fricke, Jennifer Lee, Malwina Michalak, Uwe Warnken, Ingrid Hausser, Meggy Suarez-Carmona, Niels Halama, Martina Schnölzer, Jürgen Kopitz and Johannes Gebert |
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| E-Jahr: | 2017 |
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| Jahr: | 4 April 2017 |
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| Fussnoten: | Gesehen am 04.05.2017 |
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| Titel Quelle: | Enthalten in: Cell communication and signaling |
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| Ort Quelle: | London : Biomed Central, 2003 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 15(2017) Artikel-Nummer 14, 14 Seiten |
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| ISSN Quelle: | 1478-811X |
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| Abstract: | Colorectal cancers (CRCs) that lack DNA mismatch repair function exhibit the microsatellite unstable (MSI) phenotype and are characterized by the accumulation of frameshift mutations at short repetitive DNA sequences (microsatellites). These tumors recurrently show inactivating frameshift mutations in the tumor suppressor Transforming Growth Factor Beta Receptor Type 2 (TGFBR2) thereby abrogating downstream signaling. How altered TGFBR2 signaling affects exosome-mediated communication between MSI tumor cells and their environment has not been resolved. Here, we report on molecular alterations of exosomes shed by MSI cells and the biological response evoked in recipient cells. |
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| DOI: | doi:10.1186/s12964-017-0169-y |
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| URL: | Kostenfrei: Volltext: http://dx.doi.org/10.1186/s12964-017-0169-y |
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| | DOI: https://doi.org/10.1186/s12964-017-0169-y |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Colorectal cancer |
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| | DNA mismatch repair deficiency |
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| | Exosomes |
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| | Intercellular communication |
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| | Microsatellite instability |
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| | Proteomics |
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| | Transforming Growth Factor Beta Receptor Type 2 |
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| K10plus-PPN: | 1557923345 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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TGFBR2-dependent alterations of exosomal cargo and functions in DNA mismatch repair-deficient HCT116 colorectal cancer cells / Fricke, Fabia [VerfasserIn]; 4 April 2017 (Online-Ressource)
