Online-Ressource | |
Verfasst von: | Niehaus, Antje [VerfasserIn] |
Stegmüller, Judith [VerfasserIn] | |
Diers-Fenger, Marianne [VerfasserIn] | |
Trotter, Jacqueline [VerfasserIn] | |
Titel: | Cell-surface glycoprotein of oligodendrocyte progenitors involved in migration |
Verf.angabe: | Antje Niehaus, Judith Stegmüller, Marianne Diers-Fenger, Jacqueline Trotter |
Umfang: | 14 S. |
Fussnoten: | Gesehen am 19.06.2017 |
Titel Quelle: | Enthalten in: The journal of neuroscience |
Jahr Quelle: | 1999 |
Band/Heft Quelle: | 19(1999), 12, S. 4948-4961 |
ISSN Quelle: | 1529-2401 |
Abstract: | Myelination by oligodendrocytes in the CNS involves the migration to and recognition and ensheathment of axons. These distinct developmental phases of myelination are assumed to involve the interplay of a precisely regulated set of cell adhesion molecules expressed by both neurons and glial cells. These molecules remain largely unelucidated. In this paper we have identified a large (330 kDa) glycoprotein expressed by murine oligodendrocyte progenitor cellsin vitro and in vivo that is downregulated as oligodendrocytes mature. Antigen-positive oligodendrocyte progenitor cells purified by panning develop into myelin-associated glycoprotein-positive oligodendrocytes and also adhere to cultured neurons. Polyclonal antibodies directed against the protein reduce the migration of oligodendrocyte progenitor cells. The observations suggest that the AN2 antigen may play a role in early stages of myelination. |
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Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 155983000X |
Verknüpfungen: | → Zeitschrift |