Free-breathing post-contrast three-dimensional T1 mapping

• Verfasst von: Weingärtner, Sebastian [VerfasserIn]
• Titel: Free-breathing post-contrast three-dimensional T1 mapping
• Titelzusatz: volumetric assessment of myocardial T1 values
• Verf.angabe: Sebastian Weingärtner, Mehmet Akçakaya, Sébastien Roujol, Tamer Basha, Christian Stehning, Kraig V. Kissinger, Beth Goddu, Sophie Berg, Warren J. Manning, and Reza Nezafat
• Jahr des Originals: 2014
• Umfang: 9 S.
• Fussnoten: Gesehen am 30.08.2017 ; Im Titel ist "1" tiefgestellt
• Titel Quelle: Enthalten in: Magnetic resonance in medicine
• Jahr Quelle: 2015
• Band/Heft Quelle: 73(2015), 1, S. 214-222
• ISSN Quelle: 1522-2594
• DOI: doi:10.1002/mrm.25124
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1562896830

Abstract

Purpose: To develop a three-dimensional (3D) free-breathing myocardial T1 mapping sequence for assessment of left ventricle diffuse fibrosis after contrast administration. Methods: In the proposed sequence, multiple 3D inversion recovery images are acquired in an interleaved manner. A mixed prospective/retrospective navigator scheme is used to obtain the 3D Cartesian k-space data with fully sampled center and randomly undersampled outer k-space. The resulting undersampled 3D k-space data are then reconstructed using compressed sensing. Subsequently, T1 maps are generated by voxel-wise curve fitting of the individual interleaved images. In a phantom study, the accuracy of the 3D sequence was evaluated against two-dimensional (2D) modified Look-Locker inversion recovery (MOLLI) and spin-echo sequences. In vivo T1 times of the proposed method were compared with 2D multislice MOLLI T1 mapping. Subsequently, the feasibility of high-resolution 3D T1 mapping with spatial resolution of 1.7 × 1.7 × 4 mm3 was demonstrated. Results: The proposed method shows good agreement with 2D MOLLI and the spin-echo reference in phantom. No significant difference was found in the in vivo T1 times estimated using the proposed sequence and the 2D MOLLI technique (myocardium, 330 ± 66ms versus 319 ± 93 ms; blood pools, 211 ± 68 ms versus 210 ± 98 ms). However, improved homogeneity, as measured using standard deviation of the T1 signal, was observed in the 3D T1 maps. Conclusion: The proposed sequence enables high-resolution 3D T1 mapping after contrast injection during free-breathing with volumetric left ventricle coverage.