The role of the podocyte in glomerulosclerosis.

• Verfasst von: Kriz, Wilhelm [VerfasserIn]
• Verfasst von: Lemley, Kevin V. [VerfasserIn]
• Titel: The role of the podocyte in glomerulosclerosis.
• Verf.angabe: W. Kriz, K.V. Lemley
• Umfang: 9 S.
• Fussnoten: Gesehen am 08.09.2017
• Titel Quelle: Enthalten in: Current opinion in nephrology and hypertension
• Jahr Quelle: 1999
• Band/Heft Quelle: 8(1999), 4, S. 489-497
• ISSN Quelle: 1535-3842
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1563345196

Abstract

Focal segmental glomerulosclerosis is a pathological hallmark of many forms of progressive renal disease. The 'classic' lesion, based on the adhesion of the capillary tuft to Bowman's capsule, results from the loss of podocytes from the capillary basement membrane. The recently described 'collapsing' variant, in contrast, has an apparent excess of extracapillary cells, which may represent dedifferentiated, 'dysregulated' podocytes.