Online resource | |
Verfasst von: | Helms, Gesa [VerfasserIn] |
Dasanna, Anil Kumar [VerfasserIn] | |
Schwarz, Ulrich S. [VerfasserIn] | |
Lanzer, Michael [VerfasserIn] | |
Titel: | Modeling cytoadhesion of Plasmodium falciparum-infected erythrocytes and leukocytes |
Titelzusatz: | common principles and distinctive features |
Verf.angabe: | Gesa Helms, Anil Kumar Dasanna, Ulrich S. Schwarz, and Michael Lanzer |
E-Jahr: | 2016 |
Jahr: | 5 April 2016 |
Umfang: | 17 S. |
Fussnoten: | Gesehen am 07.12.2017 |
Titel Quelle: | Enthalten in: Vereinigung der Europäischen Biochemischen GesellschaftenFEBS letters |
Ort Quelle: | Chichester : Wiley, 1968 |
Jahr Quelle: | 2016 |
Band/Heft Quelle: | 590(2016), 13, Seite 1955-1971 |
ISSN Quelle: | 1873-3468 |
Abstract: | Cytoadhesion of Plasmodium falciparum-infected erythrocytes to the microvascular endothelial lining shares striking similarities to cytoadhesion of leukocytes. In both cases, adhesins are presented in structures that raise them above the cell surface. Another similarity is the enhancement of adhesion under physical force (catch bonding). Here, we review recent advances in our understanding of the molecular and biophysical mechanisms underlying cytoadherence in both cellular systems. We describe how imaging, flow chamber experiments, single-molecule measurements, and computational modeling have been used to decipher the relevant processes. We conclude that although the parasite seems to induce processes that resemble the cytoadherence of leukocytes, the mechanics of erythrocytes is such that the resulting behavior in shear flow is fundamentally different. |
DOI: | doi:10.1002/1873-3468.12142 |
URL: | Bibliographic entry. University members only receive access to full-texts for open access or licensed publications. Kostenfrei: Volltext ; Verlag: http://dx.doi.org/10.1002/1873-3468.12142 |
Kostenfrei: Volltext: http://onlinelibrary.wiley.com/doi/10.1002/1873-3468.12142/abstract | |
DOI: https://doi.org/10.1002/1873-3468.12142 | |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | catch bond |
cytoadhesion | |
leukocyte | |
malaria | |
mesoscopic model | |
modeling | |
K10plus-PPN: | 1566138760 |
Verknüpfungen: | → Journal |