Function and significance of MicroRNAs in benign and malignant human stem cells

• Verfasst von: Utikal, Jochen [VerfasserIn]
• Verfasst von: Abba, Mohammed L. [VerfasserIn]
• Verfasst von: Novak, Daniel [VerfasserIn]
• Verfasst von: Allgayer, Heike [VerfasserIn]
• Titel: Function and significance of MicroRNAs in benign and malignant human stem cells
• Verf.angabe: Jochen Utikal, Mohammed Abba, Daniel Novak, Marcin Moniuszko, Heike Allgayer
• E-Jahr: 2015
• Jahr: December 2015
• Umfang: 12 S.
• Fussnoten: Gesehen am 07.12.2017
• Titel Quelle: Enthalten in: Seminars in cancer biology
• Ort Quelle: London : Academic Press, 1995
• Jahr Quelle: 2015
• Band/Heft Quelle: 35(2015), C, Suppl., Seite 200-211
• ISSN Quelle: 1096-3650
• DOI: doi:10.1016/j.semcancer.2015.07.001
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Cancer stem cells
• Sach-SW: ES
• Sach-SW: IPS
• Sach-SW: Metastasis
• Sach-SW: microRNAs
• Sach-SW: MSC
• Sach-SW: Stem cells
• K10plus-PPN: 1566157676

Abstract

MicroRNAs now not only represent a significant mechanism for post-transcriptional gene regulation, but have come to be appreciated as molecules with far reaching tentacles affecting diverse processes and pathologies by modulating amongst others, cellular gene expression, epigentic mechanisms, complex signaling cascades, cell-cell communication, the immune system and microenvironmental interactions between several cell types, tissues and organ systems. In this review, we systematically reflect on the impact of miRNAs on all types of benign and malignant human stem cells, looking at the roles they play in maintaining or changing the stem cell state, and review how aberrations of their expression and function within diverse types of stem cells orchestrate carcinogenesis and metastasis. As a conclusion, we consider it striking to see how similar some miR-driven mechanisms are between different types of stem cells and cancer cells, and how this might support hypotheses of miR-driven embryologic pathway reactivation in metastasis or propose putative functions of miRs in important novel cross-topic fields such as obesity and cancer.