Two sides of one coin

• Verfasst von: Weng, Honglei [VerfasserIn]
• Verfasst von: Yuan, Xiaodong [VerfasserIn]
• Verfasst von: Liebe, Roman [VerfasserIn]
• Verfasst von: Dooley, Steven [VerfasserIn]
• Titel: Two sides of one coin
• Titelzusatz: massive hepatic necrosis and progenitor cell-mediated regeneration in acute liver failure
• Verf.angabe: Hong-Lei Weng, Xiaobo Cai, Xiaodong Yuan, Roman Liebe, Steven Dooley, Hai Li and Tai-Ling Wang
• E-Jahr: 2015
• Jahr: 16 June2015
• Umfang: 12 S.
• Fussnoten: Gesehen am 16.01.2018
• Titel Quelle: Enthalten in: Frontiers in physiology
• Ort Quelle: Lausanne : Frontiers Research Foundation, 2007
• Jahr Quelle: 2015
• Band/Heft Quelle: 6(2015) Artikel-Nummer 178, 12 Seiten
• ISSN Quelle: 1664-042X
• DOI: doi:10.3389/fphys.2015.00178
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: acute liver failure
• Sach-SW: Acute-on-chronic liver failure
• Sach-SW: liver progenitor cell
• Sach-SW: Liver Regeneration
• Sach-SW: Massive Hepatic Necrosis
• K10plus-PPN: 1567192351

Abstract

Massive hepatic necrosis is a key event underlying acute liver failure, a serious clinical syndrome with high mortality. Massive hepatic necrosis in acute liver failure has unique pathophysiological characteristics including extremely rapid parenchymal cell death and removal. On the other hand, massive necrosis rapidly induces the activation of liver progenitor cells, the so-called “second pathway of liver regeneration”. The final clinical outcome of acute liver failure depends on whether liver progenitor cell-mediated regeneration can efficiently restore parenchymal mass and function within a short time. This review summarizes the current knowledge regarding massive hepatic necrosis and liver progenitor cell-mediated regeneration in patients with acute liver failure, the two sides of one coin.