Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Gebert, Johannes [VerfasserIn]   i
 Kloor, Matthias [VerfasserIn]   i
 Lee, Jennifer [VerfasserIn]   i
 Kopitz, Jürgen [VerfasserIn]   i
Titel:Colonic carcinogenesis along different genetic routes
Titelzusatz:glycophenotyping of tumor cases separated by microsatellite instability/stability
Verf.angabe:Johannes Gebert, Matthias Kloor, Jennifer Lee, Michaela Lohr, Sabine André, Rudolf Wagner, Juergen Kopitz, Hans-Joachim Gabius
E-Jahr:2012
Jahr:08 May 2012
Umfang:12 S.
Fussnoten:Gesehen am 25.04.2018
Titel Quelle:Enthalten in: Histochemistry and cell biology
Ort Quelle:Berlin : Springer, 1958
Jahr Quelle:2012
Band/Heft Quelle:138(2012), 2, Seite 339-350
ISSN Quelle:1432-119X
Abstract:Different genetic routes account for colonic carcinogenesis. However, when analyzing colon cancer specimens, separation into different groups based on genetic alterations is commonly not performed. Thus, we here initiate the comparative phenotyping considering microsatellite instability/stability for clinical specimens. The focus is given to glycan epitopes, expression of which is known to be modulated by signal-transducing proteins that act as key regulators of normal colon epithelial growth and differentiation. In addition to six plant lectins used as sensors, the presence of two adhesion/growth-regulatory galectins is studied. Overall, a considerable level of intra- and interindividual heterogeneity is revealed. Alterations in the proportion of stained cells between tumor-adjacent and malignant epithelia concerned plant lectins, which bind substituted N-glycan cores, α2,6-sialylated branch ends, core 1 O-glycans and N-acetylgalactosamine. A tendency for changes was noted between microsatellite-unstable and microsatellite-stable cases for core substitution (bisected N-glycan, presence of β1,6-branching) and status of α2,6-sialylation. Statistical significance was reached for presence of galectin-3, found to be elevated in microsatellite-stable compared to microsatellite-unstable tumors. These results emphasize the potential of distinct signaling pathways to regulate certain aspects of the glycophenotype in vivo and thus delineate a perspective to discern functionally relevant deviations in expression of endogenous lectins and their counter-receptors.
DOI:doi:10.1007/s00418-012-0957-9
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1007/s00418-012-0957-9
 Volltext: https://link.springer.com/article/10.1007/s00418-012-0957-9
 DOI: https://doi.org/10.1007/s00418-012-0957-9
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1572351012
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68246601   QR-Code
zum Seitenanfang