Propeptide big-endothelin, n-terminal-pro brain natriuretic peptide and mortality

• Verfasst von: Gergei, Ingrid [VerfasserIn]
• Verfasst von: Krämer, Bernhard [VerfasserIn]
• Verfasst von: Scharnagl, Hubert [VerfasserIn]
• Verfasst von: Stojakovic, Tatjana [VerfasserIn]
• Verfasst von: März, Winfried [VerfasserIn]
• Verfasst von: Mondorf, Ulrich [VerfasserIn]
• Titel: Propeptide big-endothelin, n-terminal-pro brain natriuretic peptide and mortality
• Titelzusatz: the Ludwigshafen risk and cardiovascular health (LURIC) study
• Verf.angabe: Ingrid Gergei, Bernhard K. Krämer, Hubert Scharnagl, Tatjana Stojakovic, Winfried März & Ulrich Mondorf
• Jahr: 2017
• Umfang: 6 S.
• Fussnoten: Published: 09 Nov 2016 ; Gesehen am 07.05.2018
• Titel Quelle: Enthalten in: Biomarkers
• Ort Quelle: London : Taylor & Francis, 1996
• Jahr Quelle: 2017
• Band/Heft Quelle: 22(2017), 3/4, Seite 315-320
• ISSN Quelle: 1366-5804
• DOI: doi:10.1080/1354750X.2016.1252969
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: big endothelin-1
• Sach-SW: biomarker
• Sach-SW: cardiovascular mortality
• Sach-SW: congestive heart failure
• Sach-SW: N-terminal-pro brain natriuretic peptide
• K10plus-PPN: 157399457X

Abstract

Context: The endothelin system (Big-ET-1) is a key regulator in cardiovascular (CV) disease and congestive heart failure (CHF).Objectives: We have examined the incremental value of Big-ET-1 in predicting total and CV mortality next to the well-established CV risk marker N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP).Methods: Big-ET-1 and NT-proBNP were determined in 2829 participants referred for coronary angiography (follow-up 9.9 years).Results: Big-ET-1 is an independent predictor of total, CV mortality and death due to CHF.Discussion: The conjunct use of Big-ET-1 and NT-proBNP improves the risk stratification of patients with intermediate to high risk of CV death and CHF.Conclusions: Big-ET-1improves risk stratification in patients referred for coronary angiography.