| |  Online-Ressource |
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| Verfasst von: | Morath, Christian [VerfasserIn]  |
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| | Zeier, Martin [VerfasserIn] |
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| | Süsal, Caner [VerfasserIn] |
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| | Beimler, Jörg [VerfasserIn] |
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| | Opelz, Gerhard [VerfasserIn] |
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| | Scherer, Sabine [VerfasserIn] |
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| | Schmidt, Jan [VerfasserIn] |
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| | Macher-Göppinger, Stephan [VerfasserIn] |
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| | Klein, Katrin [VerfasserIn] |
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| | Sommerer, Claudia [VerfasserIn] |
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| | Schwenger, Vedat [VerfasserIn] |
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| Titel: | Living donor kidney transplantation in crossmatch-positive patients enabled by peritransplant immunoadsorption and anti-CD20 therapy |
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| Verf.angabe: | Christian Morath; Jörg Beimler; Gerhard Opelz; Sabine Scherer; Jan Schmidt; Stephan Macher-Goeppinger; Katrin Klein; Claudia Sommerer; Vedat Schwenger; Martin Zeier; Caner Süsal |
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| E-Jahr: | 2012 |
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| Jahr: | 29 February 2012 |
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| Umfang: | 12 S. |
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| Teil: | volume:25 |
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| | year:2012 |
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| | number:5 |
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| | pages:506-517 |
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| | extent:12 |
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| Fussnoten: | Gesehen am 07.05.2018 |
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| Titel Quelle: | Enthalten in: Transplant international |
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| Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 1988 |
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| Jahr Quelle: | 2012 |
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| Band/Heft Quelle: | 25(2012), 5, Seite 506-517 |
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| ISSN Quelle: | 1432-2277 |
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| Abstract: | Living donor kidney transplantation in crossmatch-positive patients is a challenge that requires specific measures. Ten patients with positive crossmatch results (n = 9) or negative crossmatch results but strong donor-specific antibodies (DSA; n = 1) were desensitized using immunoadsorption (IA) and anti-CD20 antibody induction. IA was continued after transplantation and accompanied by HLA antibody monitoring and protocol biopsies. After a median of 10 IA treatments, all patients were desensitized successfully and transplanted. Median levels of mean fluorescence intensity (MFI) of Luminex-DSA before desensitization were 6203 and decreased after desensitization and immediately before transplantation to 891. Patients received a median of seven post-transplant IA treatments. At last visit, after a median follow-up of 19 months, 9 of 10 patients had a functioning allograft and a median Luminex-DSA of 149 MFI; serum creatinine was 1.6 mg/dl, and protein to creatinine ratio 0.1. Reversible acute antibody-mediated rejection was diagnosed in three patients. One allograft was lost after the second post-transplant year in a patient with catastrophic antiphospholipid syndrome. We describe a treatment algorithm for desensitization of living donor kidney transplant recipients that allows the rapid elimination of DSA with a low rate of side effects and results in good graft outcome. |
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| DOI: | doi:10.1111/j.1432-2277.2012.01447.x |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Kostenfrei: Volltext ; Verlag: http://dx.doi.org/10.1111/j.1432-2277.2012.01447.x |
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| | Kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1432-2277.2012.01447.x |
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| | DOI: https://doi.org/10.1111/j.1432-2277.2012.01447.x |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Bibliogr. Hinweis: | Erscheint auch als : Druck-Ausgabe: Living donor kidney transplantation in crossmatch-positive patients enabled by peritransplant immunoadsorption and anti-CD20 therapy. - 2012 |
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| Sach-SW: | antibody-mediated rejection |
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| | immunoadsorption |
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| | kidney transplantation |
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| | living donor |
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| | positive crossmatch |
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| K10plus-PPN: | 157400400X |
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| Verknüpfungen: | → Zeitschrift |
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Living donor kidney transplantation in crossmatch-positive patients enabled by peritransplant immunoadsorption and anti-CD20 therapy / Morath, Christian [VerfasserIn]; 29 February 2012 (Online-Ressource)
