IVIM-DWI of transplanted kidneys

• Verfasst von: Rheinheimer, Stephan [VerfasserIn]
• Verfasst von: Morath, Christian [VerfasserIn]
• Verfasst von: Zeier, Martin [VerfasserIn]
• Verfasst von: Kauczor, Hans-Ulrich [VerfasserIn]
• Verfasst von: Hallscheidt, Peter [VerfasserIn]
• Titel: IVIM-DWI of transplanted kidneys
• Titelzusatz: reduced diffusion and perfusion dependent on cold ischemia time
• Verf.angabe: S. Rheinheimer, F. Schneider, B. Stieltjes, C. Morath, M. Zeier, H.U. Kauczor, P. Hallscheidt
• E-Jahr: 2012
• Jahr: 10 July 2012
• Umfang: 6 S.
• Fussnoten: Gesehen am 28.05.2018
• Titel Quelle: Enthalten in: European journal of radiology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1990
• Jahr Quelle: 2012
• Band/Heft Quelle: 81(2012), 9, Seite e951-e956
• ISSN Quelle: 1872-7727
• DOI: doi:10.1016/j.ejrad.2012.06.008
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: ADC
• Sach-SW: Diffusion
• Sach-SW: Ischemia
• Sach-SW: IVIM
• Sach-SW: Kidney
• Sach-SW: Renal
• Sach-SW: Transplantation
• K10plus-PPN: 1575784580

Abstract

Purpose To evaluate the effect of cold ischemia time (CIT) of renal allografts on diffusion and perfusion using intravoxel incoherent motion (IVIM) derived parameters. Material and methods A total of 37 patients with renal allografts (CIT: 27 <15h, 10 ≥15h) and 30 individuals with healthy kidneys were examined at 1.5T using a single-shot echo-planar diffusion-weighted pulse sequence with nine b-values ranging from 0 to 800s/mm2. ADC, perfusion fraction f, and the diffusion coefficient D were calculated using the IVIM model. Parameters of allografts stratified by CIT were compared with healthy kidney groups using the Mann-Whitney U test for unpaired data. We computed the Spearman correlation coefficient for correlation with creatinine values. Results ADC, D, and f of transplanted kidneys were significantly lower than in the healthy controls. The long-CIT group showed significantly lower diffusion parameters compared with the short-CIT group [mean±SD]: ADC: 1.63±0.14μm2/ms, f: 11.90±5.22%, D: 1.55±0.25μm2/ms versus ADC: 1.79±0.13μm2/ms, f: 16.12±3.43%, D: 1.73±0.14μm2/ms, PADC, f, D<0.05. Conclusion Our results suggest that diffusion parameters, especially the ADC, depend on the CIT of the kidney allograft. Potentially, this stands for functional changes in renal allografts. Diffusion-weighted imaging could be used for follow-up examinations. Thus, diffusion parameters may help guide therapy in patients with delayed graft function.